{"id":"W4287835825","doi":"10.3390/cancers14153613","title":"Apigenin Targets MicroRNA-155, Enhances SHIP-1 Expression, and Augments Anti-Tumor Responses in Pancreatic Cancer","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"National Institute on Minority Health and Health Disparities; National Cancer Institute; University of South Florida","keywords":"Cancer research; Immune system; Pancreatic cancer; microRNA; Tumor microenvironment; Myelopoiesis; miR-155; Apigenin; Biology; Medicine; Cancer; Immunology; Stem cell; Cell biology; Haematopoiesis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009816631,0.0002433816,0.0001883012,0.0002501972,0.0001046069,0.0002246084,0.000160495,0.0001468925,0.0009811971],"category_scores_gemma":[0.00009079746,0.0001019882,0.0001415823,0.0001229316,0.0001942511,0.000178454,0.0001606921,0.0004570285,0.0002618975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002594517,"about_ca_system_score_gemma":0.0001932351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001946375,"about_ca_topic_score_gemma":0.0004512588,"domain_scores_codex":[0.999936,0.00001015798,0.000005952232,0.0000147561,0.00002110715,0.00001199156],"domain_scores_gemma":[0.9999627,0.000003910488,0.00001502332,0.000003633953,0.000003886093,0.00001081784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636158,0.00004538376,0.0001549343,0.00003649387,0.000003999035,0.00003302431,0.000007183931,0.00007568654,0.9967271,0.00008219072,0.00006231329,0.00260805],"study_design_scores_gemma":[0.00006193297,0.0009675391,0.009592445,0.000006079556,0.00003907621,0.0002822469,0.00003553569,0.001111682,0.9827209,0.0001267739,0.005048516,0.000007168497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923527,0.002531267,0.002436571,0.0001738425,0.00005153631,0.00003799425,0.0002488634,0.0001419729,0.002025227],"genre_scores_gemma":[0.9944833,0.001637859,0.001573124,0.00007862455,0.00001182542,0.00004772829,0.0002283605,0.0000192451,0.001919811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009811971,"threshold_uncertainty_score":0.003282487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137594413527403,"score_gpt":0.2650264873564633,"score_spread":0.2536505432211892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}