{"id":"W4287837534","doi":"10.3390/diagnostics12081801","title":"A Diagnostic Gene Expression Signature for Bladder Cancer Can Stratify Cases into Prescribed Molecular Subtypes and Predict Outcome","year":2022,"lang":"en","type":"article","venue":"Diagnostics","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health","keywords":"Bladder cancer; Oncology; Multiplex; Medicine; Gene signature; Internal medicine; Cancer; Gene expression; Gene expression profiling; Survival analysis; Biomarker; Disease; Bioinformatics; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008477853,0.0002663829,0.0003600397,0.00008335658,0.0002762749,0.00003158854,0.0001025137,0.0001014566,0.0003153412],"category_scores_gemma":[0.001184771,0.0002333478,0.00009734286,0.0001358814,0.00007410607,0.00004524547,0.0001265269,0.0002728657,0.000001331617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494399,"about_ca_system_score_gemma":0.0002590887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007012946,"about_ca_topic_score_gemma":0.0002391235,"domain_scores_codex":[0.9984968,0.00006259364,0.0002835446,0.0004497064,0.0003744864,0.0003329059],"domain_scores_gemma":[0.9981416,0.001123488,0.00008904385,0.0003079574,0.0001114985,0.0002263665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001478194,0.001712286,0.8793201,0.0009092337,0.001023098,0.003510411,0.00329178,0.001511603,0.04449485,0.000298746,0.05022754,0.01222213],"study_design_scores_gemma":[0.03206536,0.01397767,0.3199608,0.00098796,0.008547698,0.0008391933,0.002929037,0.001069709,0.554139,0.003916414,0.0587598,0.002807382],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697595,0.02197617,0.0004671152,0.002046107,0.0005733841,0.002296289,0.002691676,0.00009937026,0.00009035552],"genre_scores_gemma":[0.992907,0.001006593,0.001089077,0.001750659,0.0002294882,0.002163186,0.0004757185,0.00006749506,0.0003107244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5593594,"threshold_uncertainty_score":0.9515648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171644157096274,"score_gpt":0.307460816346516,"score_spread":0.2857443747755533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}