{"id":"W4287837534","doi":"10.3390/diagnostics12081801","title":"A Diagnostic Gene Expression Signature for Bladder Cancer Can Stratify Cases into Prescribed Molecular Subtypes and Predict Outcome","year":2022,"lang":"en","type":"article","venue":"Diagnostics","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health","keywords":"Bladder cancer; Oncology; Multiplex; Medicine; Gene signature; Internal medicine; Cancer; Gene expression; Gene expression profiling; Survival analysis; Biomarker; Disease; Bioinformatics; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001448054,0.0005330744,0.0007444641,0.002352311,0.0002270167,0.0009140996,0.0002745798,0.0004870368,0.0008829298],"category_scores_gemma":[0.00270611,0.0001390633,0.0005430321,0.001835986,0.0002484122,0.0004030008,0.0004066834,0.0004193624,0.0004143546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005796308,"about_ca_system_score_gemma":0.000626682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091633,"about_ca_topic_score_gemma":0.0025399,"domain_scores_codex":[0.9992871,0.0001552785,0.00006658857,0.0001980274,0.0002067157,0.00008642369],"domain_scores_gemma":[0.9981946,0.0005932089,0.0007427997,0.0001134127,0.0002213468,0.0001347112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008618908,0.0002968041,0.8092877,0.0002506354,0.0003861079,0.0001776238,0.00007014528,0.00297565,0.07802953,0.0003299516,0.002407879,0.1049261],"study_design_scores_gemma":[0.00005004188,0.0008651696,0.9110677,0.00009824867,0.0005539166,0.001308388,0.0001377405,0.02674478,0.05166359,0.001233413,0.006200552,0.0000765652],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680456,0.003802326,0.01626677,0.0006619558,0.0000982021,0.000123184,0.008286435,0.0004132198,0.002302353],"genre_scores_gemma":[0.9755219,0.000858263,0.01808427,0.0002113773,0.00006656395,0.0000812724,0.004513006,0.00002172693,0.0006416597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002352311,"threshold_uncertainty_score":0.007658124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171644157096274,"score_gpt":0.307460816346516,"score_spread":0.2857443747755533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}