{"id":"W4287838589","doi":"10.1073/pnas.2204539119","title":"SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; University of Ottawa; University of Alberta; Children's Hospital of Eastern Ontario; McGill University; Christie (Canada); University of Manitoba; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; China Scholarship Council; Queen's University; Directorate for Biological Sciences; Terry Fox Research Institute; National Research Foundation of Korea; Canada Excellence Research Chairs, Government of Canada; UK Research and Innovation; National Research Foundation; Queen's University Belfast; Government of Canada; Princess Margaret Cancer Foundation","keywords":"Innate immune system; Messenger RNA; Translation (biology); Interferon; Biology; Cell biology; Psychological repression; Immune system; Virology; RNA; Protein biosynthesis; microRNA; Viral replication; Mechanism (biology); Cytokine; Virus; Immunology; Gene expression; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389233,0.0004414949,0.0002744874,0.0001561514,0.000102157,0.0002303707,0.0001580554,0.0002635296,0.001404622],"category_scores_gemma":[0.00008322148,0.0001402689,0.0002106371,0.00008335276,0.0002256363,0.0001596631,0.0001671734,0.0006013468,0.0003506942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201204,"about_ca_system_score_gemma":0.0001788215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003581877,"about_ca_topic_score_gemma":0.0005089554,"domain_scores_codex":[0.9998517,0.00003386732,0.00001808784,0.00002345442,0.00003723452,0.00003570313],"domain_scores_gemma":[0.9999168,0.0000153431,0.00002326411,0.00001208519,0.00000603779,0.00002649581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000872577,0.00003514134,0.00005899086,0.00000989136,0.000002108192,0.00002274524,0.000003714744,0.00003846638,0.9995002,0.00003964631,0.00001576271,0.0001860026],"study_design_scores_gemma":[0.00002319364,0.0003836241,0.002486221,0.000003654818,0.00000441878,0.0001233238,0.0000167433,0.0009535527,0.9952073,0.00003383859,0.0007611733,0.000003089234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973483,0.0003404384,0.0007068303,0.00005275506,0.00002992121,0.00001751433,0.0003189861,0.00004891391,0.001136229],"genre_scores_gemma":[0.9944732,0.0003102959,0.001207505,0.00004701484,0.000009258582,0.00003967475,0.0007026695,0.00001921321,0.003191157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404622,"threshold_uncertainty_score":0.004698873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632425264555622,"score_gpt":0.3247269218442627,"score_spread":0.2584026691987065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}