{"id":"W4287838589","doi":"10.1073/pnas.2204539119","title":"SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; University of Ottawa; University of Alberta; Children's Hospital of Eastern Ontario; McGill University; Christie (Canada); University of Manitoba; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; China Scholarship Council; Queen's University; Directorate for Biological Sciences; Terry Fox Research Institute; National Research Foundation of Korea; Canada Excellence Research Chairs, Government of Canada; UK Research and Innovation; National Research Foundation; Queen's University Belfast; Government of Canada; Princess Margaret Cancer Foundation","keywords":"Innate immune system; Messenger RNA; Translation (biology); Interferon; Biology; Cell biology; Psychological repression; Immune system; Virology; RNA; Protein biosynthesis; microRNA; Viral replication; Mechanism (biology); Cytokine; Virus; Immunology; Gene expression; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001417969,0.00008551533,0.000168095,0.0002352583,0.0002882368,0.000004037577,0.00056348,0.00007958836,0.00005514263],"category_scores_gemma":[0.0002492115,0.00006103828,0.00009853447,0.0004666174,0.0004832292,0.0002726586,0.0001542738,0.0002667288,0.000001950081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000044609,"about_ca_system_score_gemma":0.00003185735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001789162,"about_ca_topic_score_gemma":7.518901e-8,"domain_scores_codex":[0.9989237,0.00004924618,0.0004105278,0.0002261181,0.0002640105,0.0001264612],"domain_scores_gemma":[0.9991894,0.00006925276,0.0005469001,0.00001381602,0.000176583,0.000004090723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004268889,0.00008597935,0.0002796921,0.00002853729,0.0000232644,1.532882e-9,0.0007962023,0.00002323183,0.9946497,0.0009748171,0.0006408371,0.002070843],"study_design_scores_gemma":[0.0002345228,0.0003463445,0.004708814,0.00006469945,0.00001308694,0.00002919003,0.0005009542,0.00006761382,0.991534,0.001990326,0.0004494559,0.00006097781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996154,0.0003821811,0.000001345637,0.001721996,0.0001564693,0.0002056155,0.000009486324,0.00001259054,0.00135637],"genre_scores_gemma":[0.9995941,0.00001352952,0.00006951895,0.00006459481,0.00001616291,0.00001506839,6.891087e-7,0.000003911757,0.0002224333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004429122,"threshold_uncertainty_score":0.2489069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632425264555622,"score_gpt":0.3247269218442627,"score_spread":0.2584026691987065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}