{"id":"W4287877726","doi":"10.3390/pharmaceutics14081546","title":"Localized Controlled Release of Kynurenic Acid Encapsulated in Synthetic Polymer Reduces Implant—Induced Dermal Fibrosis","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Wound Healing and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia; Spinal Cord Injury BC","funders":"Faculty of Pharmaceutical Sciences, University of British Columbia; Canadian Institutes of Health Research","keywords":"In vivo; PLGA; Fibrosis; Chemistry; Wound healing; Kynurenic acid; Controlled release; Pharmacology; Drug delivery; In vitro; Biomedical engineering; Surgery; Medicine; Biochemistry; Glutamate receptor; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633218,0.0003067501,0.0003430716,0.000205846,0.00008889687,0.0002615145,0.0001624384,0.000267466,0.0007118328],"category_scores_gemma":[0.0001491335,0.0001334656,0.000243847,0.0001085619,0.00020796,0.000312832,0.0001595782,0.0003268232,0.0001510961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001555448,"about_ca_system_score_gemma":0.000199648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510568,"about_ca_topic_score_gemma":0.0005163724,"domain_scores_codex":[0.999897,0.000016439,0.000009516922,0.00002429534,0.00002523517,0.00002740775],"domain_scores_gemma":[0.999886,0.00002199627,0.00005068692,0.000009865602,0.000009987008,0.00002140439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001514465,0.00004179649,0.00004654698,0.00003792965,0.000003965828,0.00001645915,0.000006866983,0.00007635084,0.9983227,0.00002347351,0.000007628755,0.001264802],"study_design_scores_gemma":[0.00003901038,0.001202438,0.001119107,0.000006993022,0.00002366684,0.00005974279,0.00001276572,0.0008338615,0.9959856,0.00001263758,0.0006988159,0.000005281459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949941,0.001545753,0.002825659,0.00003144856,0.00002638318,0.00003866321,0.00006212242,0.00004694397,0.0004289641],"genre_scores_gemma":[0.9948307,0.0009521979,0.002890786,0.0000188145,0.00001145012,0.00003462232,0.00007349355,0.00001562221,0.001172394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007118328,"threshold_uncertainty_score":0.002381325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04384041145816906,"score_gpt":0.3515018393616952,"score_spread":0.3076614279035261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}