{"id":"W4287958183","doi":"10.1016/j.euros.2022.06.007","title":"Combining Antiandrogens with Immunotherapy for Bladder Cancer Treatment","year":2022,"lang":"en","type":"article","venue":"European Urology Open Science","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Janssen Pharmaceuticals; Fonds de Recherche du Québec - Santé; Ferring Pharmaceuticals; Astellas Pharma Canada; Canadian Cancer Society Research Institute; Bayer; Cancer Research Society; AbbVie; Merck; Sanofi; Bristol-Myers Squibb; Amgen","keywords":"Enzalutamide; Immunotherapy; Medicine; Immune system; Bladder cancer; Prostate cancer; Cancer research; Cancer; Androgen receptor; Oncology; Antiandrogens; In vivo; Durvalumab; Internal medicine; Immunology; Biology; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000252577,0.0002370157,0.0004002063,0.0004224431,0.0001257341,0.0003405678,0.0002458298,0.0002135894,0.001762877],"category_scores_gemma":[0.0001456013,0.00008444128,0.0004991781,0.0002799781,0.0001592974,0.0001579966,0.0002430912,0.0004687215,0.0003603607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163278,"about_ca_system_score_gemma":0.0004706189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002786711,"about_ca_topic_score_gemma":0.001134673,"domain_scores_codex":[0.9998478,0.00004762676,0.00001151579,0.00002066226,0.00004164314,0.00003078595],"domain_scores_gemma":[0.9999149,0.00001653811,0.00002432897,0.00001141629,0.00000911327,0.00002383587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004594093,0.002627394,0.00769684,0.0024908,0.0005993951,0.000457759,0.00008932888,0.002637099,0.5074647,0.001038901,0.002721399,0.4675823],"study_design_scores_gemma":[0.003734231,0.07877433,0.09028524,0.0008252465,0.002102512,0.006883643,0.0002068794,0.005573393,0.5336722,0.00236507,0.2754855,0.00009175393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8470317,0.1303839,0.00716798,0.00188653,0.0006379979,0.0007016472,0.0007627414,0.0003130717,0.0111145],"genre_scores_gemma":[0.9621462,0.02861908,0.004767836,0.0005109005,0.0003208135,0.0002455839,0.0004252191,0.00002170299,0.002942805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762877,"threshold_uncertainty_score":0.005897403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04154729608095371,"score_gpt":0.3384467890099285,"score_spread":0.2968994929289748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}