{"id":"W4287981445","doi":"10.1093/ibd/izac157","title":"Increased Expression of Interleukin-13 Receptor in Ileum Associated With Nonresponse to Adalimumab in Ileal Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"AbbVie","keywords":"Medicine; Crohn's disease; Adalimumab; Internal medicine; Gastroenterology; Ileum; Odds ratio; Immunohistochemistry; Biopsy; Infliximab; Inflammatory bowel disease; Biomarker; Pathology; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001169632,0.0002285958,0.0004329613,0.00046226,0.0002349716,0.0005476802,0.0002992298,0.0003027802,0.001262866],"category_scores_gemma":[0.002195672,0.0001841986,0.0005395611,0.0004534616,0.0003859085,0.0002972965,0.0003717209,0.0006265951,0.0001671514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001767037,"about_ca_system_score_gemma":0.0002081779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004399043,"about_ca_topic_score_gemma":0.0006335259,"domain_scores_codex":[0.9994752,0.0001845527,0.00005327758,0.000103871,0.00009725436,0.00008598709],"domain_scores_gemma":[0.9966449,0.0009306642,0.00165778,0.000186924,0.0002025252,0.0003771215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008421145,0.00002329673,0.9970999,0.00001253811,0.00003773225,0.000152605,0.00002114796,0.00002860105,0.000717639,0.000005717624,0.00002248811,0.00103621],"study_design_scores_gemma":[0.00001391938,0.0001795117,0.9986826,0.00000366771,0.00004218625,0.0006983526,0.0000442779,0.0001522649,0.0001100012,0.00000881126,0.00006261963,0.000001867466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995671,0.0002166988,0.00005770079,0.00001407916,0.00000258706,0.000002907495,0.00002421729,0.000001682254,0.0001131179],"genre_scores_gemma":[0.999818,0.00003438094,0.00004103095,0.000007123369,0.000005922072,0.000002024632,0.00004775519,8.169876e-7,0.00004289894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262866,"threshold_uncertainty_score":0.00618571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006319198909583283,"score_gpt":0.2254873609221536,"score_spread":0.2191681620125703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}