{"id":"W4288038565","doi":"10.1371/journal.pone.0270584","title":"Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Dental and Craniofacial Research; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health; National Health and Medical Research Council","keywords":"Granzyme; Proteases; Granzyme A; Protease-activated receptor 2; Cell biology; Granzyme B; Serine protease; Protease; Protease-activated receptor; Biology; Chemistry; Phosphorylation; Receptor; Immune system; Molecular biology; Biochemistry; Cytotoxic T cell; T cell; Perforin; Immunology; Enzyme; Enzyme-linked receptor; Thrombin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389825,0.000415237,0.0003651017,0.0003255479,0.0001620078,0.000599565,0.0001644112,0.0005379003,0.001870872],"category_scores_gemma":[0.0002813924,0.000208547,0.0005478624,0.0001423022,0.0002024218,0.0004627864,0.0005721402,0.0008371861,0.001010234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506208,"about_ca_system_score_gemma":0.000195629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002217608,"about_ca_topic_score_gemma":0.0002101969,"domain_scores_codex":[0.999725,0.00006118129,0.00001993053,0.00003912739,0.00004596298,0.0001087069],"domain_scores_gemma":[0.9998897,0.000015765,0.00003204629,0.00001506642,0.00001703466,0.00003037405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006099628,0.00004241459,0.000513842,0.00009866053,0.00001270384,0.0004144649,0.00004854387,0.0000904359,0.9954442,0.0002010216,0.0001610654,0.002362655],"study_design_scores_gemma":[0.000192045,0.0006709375,0.01880804,0.00003688372,0.00003486906,0.001532733,0.0003035797,0.002865446,0.9684615,0.0006482034,0.006431608,0.00001420917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862928,0.005148229,0.004506493,0.0005521742,0.0001157923,0.00008239935,0.0004006931,0.0001872067,0.002714058],"genre_scores_gemma":[0.9919992,0.001822727,0.002252081,0.000184046,0.0000440385,0.00005325793,0.0003026631,0.00002095676,0.003321101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870872,"threshold_uncertainty_score":0.006258667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04230428784026861,"score_gpt":0.2337939828240955,"score_spread":0.1914896949838269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}