{"id":"W4288050624","doi":"10.7554/elife.76038","title":"Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Translation (biology); Messenger RNA; Biology; Nonsense-mediated decay; Protein biosynthesis; Cell biology; Eukaryotic translation; Genetics; Computational biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170044,0.0001185302,0.0001008501,0.00002922104,0.0003510284,0.00002298401,0.0001045279,0.00005121097,0.00003563743],"category_scores_gemma":[0.00004992302,0.0001114437,0.00005943103,0.00006571165,0.00001474385,0.000006330061,0.00003032134,0.00005601376,0.000001763443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002547135,"about_ca_system_score_gemma":0.00004164794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006882701,"about_ca_topic_score_gemma":0.00005383788,"domain_scores_codex":[0.9991254,0.00007267556,0.0001635107,0.0002733505,0.0002073991,0.0001576542],"domain_scores_gemma":[0.9995492,0.00001946293,0.0001422432,0.0001866806,0.00005852088,0.00004386916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004936188,0.00005454973,0.002970438,0.00004009372,0.00003140138,0.000002286902,0.00009960956,0.0001976645,0.9883566,0.00008646481,0.00006919872,0.007598091],"study_design_scores_gemma":[0.001500475,0.0006705057,0.03844887,0.00002379548,0.00004256766,0.00001226116,0.0002625272,0.0004189709,0.9459307,0.0002047126,0.01211141,0.0003732695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586561,0.0001760083,0.04011919,0.0001368877,0.00008865096,0.000517546,0.0001438536,0.00002698549,0.0001347763],"genre_scores_gemma":[0.995724,0.00001046808,0.002498544,0.00004746502,0.0001788562,0.0003711079,0.0008761754,0.00002876123,0.0002646472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04242594,"threshold_uncertainty_score":0.4544542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215256256883492,"score_gpt":0.2259177732177156,"score_spread":0.2043921475293664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}