{"id":"W4288058052","doi":"10.1210/clinem/dgac433","title":"Burosumab Treatment for Autosomal Recessive Hypophosphatemic Rickets Type 1 (ARHR1)","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Osteomalacia; Hypophosphatemia; Medicine; Rickets; Hypophosphatemic Rickets; Internal medicine; Fibroblast growth factor 23; Endocrinology; Bone pain; Calcitriol; DMP1; Nephrocalcinosis; Population; Vitamin D and neurology; Kidney; Parathyroid hormone; Calcium; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063159,0.0002409843,0.0003713927,0.0002138521,0.0002560516,0.0001481253,0.0002492798,0.0004136074,0.001269242],"category_scores_gemma":[0.0002254277,0.00006333752,0.0001744603,0.0001587562,0.0001432407,0.000105141,0.0002171115,0.0004995017,0.0002143663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223058,"about_ca_system_score_gemma":0.0002091302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003333395,"about_ca_topic_score_gemma":0.001092063,"domain_scores_codex":[0.9999331,0.00001846838,0.000007832155,0.00001281502,0.00001615873,0.00001145316],"domain_scores_gemma":[0.9999173,0.00001875856,0.00002774046,0.000004946038,0.000007166501,0.00002406007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.007917218,0.001787907,0.02547119,0.002494827,0.0003760427,0.03689166,0.0006016027,0.001119402,0.4170241,0.001264665,0.004345281,0.5007061],"study_design_scores_gemma":[0.004218412,0.04696624,0.2276077,0.001491595,0.0010119,0.3110726,0.0007264026,0.00384747,0.2257451,0.00150252,0.1756666,0.0001435042],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9411924,0.04752003,0.003135758,0.0009889923,0.0001453429,0.0001208009,0.0002303371,0.0001604051,0.006505989],"genre_scores_gemma":[0.9913114,0.00537148,0.001711733,0.0003444524,0.00005181881,0.00003603315,0.000152185,0.000008316214,0.001012619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269242,"threshold_uncertainty_score":0.004246056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09042515287279346,"score_gpt":0.4168522402555186,"score_spread":0.3264270873827251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}