{"id":"W4288060882","doi":"10.1016/j.ijrobp.2022.07.035","title":"Metformin for Prevention of Anthropometric and Metabolic Complications of Androgen Deprivation Therapy in Prostate Cancer Patients Receiving Radical Radiotherapy: A Phase II Randomized Controlled Trial","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; Research Manitoba; University of Calgary; University of Manitoba","funders":"","keywords":"Medicine; Androgen deprivation therapy; Prostate cancer; Metformin; Placebo; Internal medicine; Randomized controlled trial; Body mass index; Waist; Urology; Surgery; Cancer; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001203413,0.001738874,0.003666029,0.0004099745,0.00050638,0.001320111,0.0009408434,0.002113977,0.005697749],"category_scores_gemma":[0.001498141,0.0008426937,0.00255628,0.0005394529,0.0009411286,0.0009299039,0.0004750335,0.003593323,0.000572581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006663542,"about_ca_system_score_gemma":0.0009839508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916872,"about_ca_topic_score_gemma":0.003409941,"domain_scores_codex":[0.9995638,0.0002016243,0.00002933763,0.00009190916,0.00003135153,0.00008205891],"domain_scores_gemma":[0.9994065,0.0001751076,0.0001437563,0.00004517308,0.00003705973,0.0001924239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9806862,0.004737734,0.0008466754,0.0008373114,0.002685932,0.0000298691,0.00003210286,0.0002615467,0.0008919205,0.00006635616,0.0004473566,0.00847687],"study_design_scores_gemma":[0.9673043,0.02834173,0.001971561,0.0000616674,0.001535022,0.00001408979,0.00002098027,0.0002440808,0.0001277839,0.00007753466,0.0002879677,0.00001332634],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765958,0.01499928,0.0007045222,0.001044819,0.001050733,0.00296563,0.0008110176,0.0001235722,0.001704712],"genre_scores_gemma":[0.9845358,0.006934155,0.0012234,0.001445984,0.0006613664,0.002301503,0.0006113362,0.00002017174,0.002266368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005697749,"threshold_uncertainty_score":0.01906091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673617319989538,"score_gpt":0.3501248654541933,"score_spread":0.3333886922542979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}