{"id":"W4288066063","doi":"10.1097/shk.0000000000001804","title":"Mechanistic Studies of DNase I Activity: Impact of Heparin Variants and PAD4","year":2021,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Histone; Neutrophil extracellular traps; Deoxyribonuclease I; DNA; Hypersensitive site; Molecular biology; Histone H4; Nucleosome; Chemistry; Biochemistry; Biology; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307748,0.0001461526,0.0004581237,0.00006303252,0.00006167882,0.00000348611,0.00007431457,0.0001016288,0.0002813339],"category_scores_gemma":[0.0001455021,0.0001160151,0.00009684198,0.0001300202,0.0001366197,0.0000545146,0.0001620304,0.0001221485,0.000021643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002486515,"about_ca_system_score_gemma":0.00009680785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008819472,"about_ca_topic_score_gemma":0.00002985967,"domain_scores_codex":[0.9991681,0.0001785171,0.000197077,0.0002318543,0.00003005338,0.0001943774],"domain_scores_gemma":[0.9993177,0.0001588563,0.0001192287,0.0002371412,0.0001475913,0.00001945735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001292883,0.0001144736,0.0002831148,0.00005716669,0.0006462414,0.00002985611,0.0002402875,0.000001330625,0.9892017,0.003928421,0.0001589179,0.005209182],"study_design_scores_gemma":[0.0007487458,0.0004625898,0.004802602,0.00006361138,0.00009311154,0.00005715799,0.0002895687,0.000003918342,0.989908,0.00334211,0.0001168798,0.0001117524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953116,0.003431448,0.0005827819,0.00004890721,0.0001863243,0.00009779675,0.00009590296,0.00001335078,0.0002319331],"genre_scores_gemma":[0.9982755,0.0005500636,0.0002228761,0.00002604259,0.00001077053,0.000003695108,0.00001725027,0.00001071923,0.0008831299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00509743,"threshold_uncertainty_score":0.4730957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785294485800508,"score_gpt":0.3196794767786401,"score_spread":0.281826531920635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}