{"id":"W4288067823","doi":"10.1002/advs.202201294","title":"Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi","keywords":"In vivo; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Neutralization; Potency; Monoclonal antibody; In vitro; Coronavirus disease 2019 (COVID-19); IC50; Chemistry; Virology; 2019-20 coronavirus outbreak; Antibody; Cell biology; Biology; Biochemistry; Virus; Medicine; Immunology; Infectious disease (medical specialty); Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007738773,0.00009070623,0.0001742799,0.0006288944,0.0001531715,0.00001487405,0.0001379216,0.00002672305,0.000006307143],"category_scores_gemma":[0.0003421249,0.00009140593,0.00002283052,0.002495817,0.0003034256,0.0002200183,0.0001351049,0.0001767533,0.000001172091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400093,"about_ca_system_score_gemma":0.0004140125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349271,"about_ca_topic_score_gemma":0.0001055247,"domain_scores_codex":[0.9983945,0.00005360177,0.0002239827,0.0003872513,0.0006199666,0.0003206586],"domain_scores_gemma":[0.999537,0.00005187102,0.00007719184,0.0002185944,0.0000905129,0.0000248167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004300757,0.0002137118,0.02208266,0.00005075054,9.043947e-7,0.000009308499,0.0001876424,0.00132458,0.9724514,0.000008626714,0.000001511843,0.003238765],"study_design_scores_gemma":[0.001880262,0.0002454548,0.004860797,0.00005309877,0.000002295673,0.000004432411,0.00006625576,0.06973444,0.9221323,0.00003007141,0.0009095205,0.00008103334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978439,0.00008027744,0.0007934142,0.00009818856,0.00007133613,0.0007992135,0.000002997731,0.00002438218,0.0002863302],"genre_scores_gemma":[0.9974957,0.000001460843,0.001207302,0.001113622,0.000006238748,0.0001473141,0.000001141801,0.000008193987,0.00001905381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06840986,"threshold_uncertainty_score":0.3727426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262079151383265,"score_gpt":0.3358367439087642,"score_spread":0.3132159523949316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}