{"id":"W4288067823","doi":"10.1002/advs.202201294","title":"Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi","keywords":"In vivo; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Neutralization; Potency; Monoclonal antibody; In vitro; Coronavirus disease 2019 (COVID-19); IC50; Chemistry; Virology; 2019-20 coronavirus outbreak; Antibody; Cell biology; Biology; Biochemistry; Virus; Medicine; Immunology; Infectious disease (medical specialty); Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555844,0.0002982216,0.0002627391,0.000109424,0.00008594302,0.0001769561,0.0001573608,0.0001910815,0.001023217],"category_scores_gemma":[0.00009663292,0.00007797536,0.0001517415,0.00007804841,0.0001548183,0.0001235249,0.00009962186,0.000410641,0.0002572192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475468,"about_ca_system_score_gemma":0.0001399912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383785,"about_ca_topic_score_gemma":0.000712072,"domain_scores_codex":[0.9998984,0.00001829521,0.000006494927,0.00001745218,0.00002831146,0.00003099798],"domain_scores_gemma":[0.9999402,0.00001143912,0.00001595879,0.000008075846,0.000005586506,0.00001869106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730349,0.00009800698,0.00009301033,0.0000271421,0.00001055443,0.00001739249,0.000006856082,0.0001685985,0.9981943,0.00006750751,0.0001007533,0.001042885],"study_design_scores_gemma":[0.00005949778,0.001370764,0.001274693,0.000002562869,0.00001046338,0.0001303504,0.000007397366,0.002109714,0.9934278,0.00001747117,0.001586497,0.000002808687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962447,0.0008001497,0.001820185,0.0000492214,0.00003014891,0.00002256593,0.000181028,0.00007697309,0.0007749476],"genre_scores_gemma":[0.9962465,0.0003069744,0.001524144,0.00002642697,0.00001153978,0.00001847844,0.0004738783,0.00001180245,0.001380236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023217,"threshold_uncertainty_score":0.003422976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262079151383265,"score_gpt":0.3358367439087642,"score_spread":0.3132159523949316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}