{"id":"W4288067911","doi":"10.1002/cpt.2721","title":"Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long‐Term Response to Atrasentan in Patients With Diabetic Kidney Disease","year":2022,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Horizon 2020 Framework Programme; Innovative Medicines Initiative; European Commission; Steno Diabetes Center Copenhagen; European Federation of Pharmaceutical Industries and Associations","keywords":"Transporter; Diabetes mellitus; Organic anion transporter 1; Kidney disease; Kidney; Pharmacology; Medicine; Plasma concentration; Gene; Chemistry; Internal medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009107495,0.0003349699,0.0006305712,0.0002715828,0.0002980215,0.0004465475,0.0003184082,0.0006843735,0.000898027],"category_scores_gemma":[0.001606767,0.0003255454,0.0007432887,0.0005450727,0.0002218246,0.0003023594,0.0002389022,0.0006825715,0.0001161747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995388,"about_ca_system_score_gemma":0.0001400823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916031,"about_ca_topic_score_gemma":0.002001047,"domain_scores_codex":[0.9994414,0.000197277,0.00006264623,0.0001699954,0.0000568453,0.00007172405],"domain_scores_gemma":[0.9987108,0.0004228157,0.0004562296,0.0001438042,0.00007359676,0.0001928661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004373681,0.000160344,0.9903269,0.00001887318,0.0004071891,0.0002556363,0.00007287741,0.0001658925,0.002084512,0.0000267281,0.0001241662,0.001983155],"study_design_scores_gemma":[0.0001594422,0.0005704217,0.9979231,0.000005479021,0.0001749616,0.0002925094,0.00003374702,0.0005136945,0.0001800839,0.00003836914,0.0001001993,0.000008042594],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994529,0.0002408395,0.00006744228,0.00002347487,0.000006387423,0.000004208258,0.0001080391,0.000002193314,0.00009447533],"genre_scores_gemma":[0.9995814,0.00004910227,0.00006482824,0.00003532915,0.00001126642,0.000006692588,0.0001431708,0.000001747575,0.0001064638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916031,"threshold_uncertainty_score":0.004816532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02296220609710057,"score_gpt":0.3322508767920141,"score_spread":0.3092886706949135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}