{"id":"W4288068653","doi":"10.3389/fonc.2022.867462","title":"Karnofsky Performance Status (KPS) ≤60 Is Strongly Associated With Shorter Brain-Specific Progression-Free Survival Among Patients With Metastatic Breast Cancer With Brain Metastases","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Medicine; Internal medicine; Breast cancer; Cohort; Oncology; Radiosurgery; Proportional hazards model; Radiation therapy; Cancer; Metastatic breast cancer; Retrospective cohort study; Brain metastasis; Karnofsky Performance Status; Disease; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008243948,0.000593024,0.00131755,0.0004362863,0.0003718626,0.00003825573,0.0003281157,0.00009680206,0.001005942],"category_scores_gemma":[0.00005063709,0.0003910891,0.000108843,0.001012166,0.0006410045,0.0002756312,0.0001989123,0.0008065091,0.000002528455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002032,"about_ca_system_score_gemma":0.0009288779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002938944,"about_ca_topic_score_gemma":0.001051294,"domain_scores_codex":[0.9951785,0.0008158915,0.0005723405,0.0009261049,0.001343959,0.001163168],"domain_scores_gemma":[0.9978037,0.0003287917,0.0005140969,0.0007408188,0.0002342466,0.0003783591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00779006,0.002913834,0.9065319,0.00005558504,0.002101359,0.0009105842,0.001037973,0.0008969185,0.00000190448,0.00002055309,0.04680802,0.03093126],"study_design_scores_gemma":[0.0281708,0.01322955,0.9240588,0.000257324,0.0008915167,0.00009179561,0.003141411,0.0005206785,0.00001911621,0.00001978347,0.02901014,0.0005890769],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888349,0.0008282577,0.0005695572,0.004148318,0.0005239648,0.002209472,0.002400282,0.00008659958,0.0003986645],"genre_scores_gemma":[0.9815601,0.00008493777,0.01340329,0.001263236,0.00006777171,0.00137372,0.001325633,0.0001463775,0.0007750088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03034219,"threshold_uncertainty_score":0.9999073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250583957558689,"score_gpt":0.2695256784874261,"score_spread":0.2570198389118392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}