{"id":"W4288068679","doi":"10.1007/s10571-022-01261-0","title":"Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin","year":2022,"lang":"en","type":"review","venue":"Cellular and Molecular Neurobiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ubiquitin ligase; Biology; Ubiquitin; Glioma; Cancer research; Proteasome; Hippo signaling pathway; Notch signaling pathway; SKP2; Gene; Cell biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003323361,0.0002893586,0.0004970372,0.001835855,0.000246367,0.0005074759,0.0001724623,0.0002262018,0.0007886186],"category_scores_gemma":[0.0007421506,0.00009555888,0.0004185857,0.0023429,0.0001884861,0.0001876646,0.0004935493,0.0001763944,0.0003589289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298741,"about_ca_system_score_gemma":0.000374627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00185936,"about_ca_topic_score_gemma":0.004509846,"domain_scores_codex":[0.9994104,0.00006482715,0.00005424131,0.0002112082,0.0001358994,0.0001234538],"domain_scores_gemma":[0.9994785,0.0001606819,0.0001788631,0.00006572378,0.00006701879,0.00004930734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001601652,0.00015948,0.660012,0.001363566,0.000660843,0.0007491246,0.0003961583,0.003437308,0.2546976,0.0007411875,0.004492481,0.07168869],"study_design_scores_gemma":[0.0000359966,0.0001653685,0.9612159,0.00006145541,0.0002921212,0.0007301008,0.000296919,0.002633051,0.02089287,0.0007977643,0.01285649,0.00002198373],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9380465,0.001967137,0.00134338,0.0001043008,0.0000110092,0.00002351945,0.05684756,0.0001455627,0.001511197],"genre_scores_gemma":[0.8654862,0.001045918,0.004073101,0.000133179,0.000017106,0.00007923278,0.1284162,0.00004269294,0.0007064336],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00185936,"threshold_uncertainty_score":0.003697097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027347966428055,"score_gpt":0.2603938741210873,"score_spread":0.2401203944568068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}