{"id":"W4288077431","doi":"10.3390/cancers14153665","title":"MORPHEUS Phase II–III Study: A Pre-Planned Interim Safety Analysis and Preliminary Results","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; McGill University; Jewish General Hospital","funders":"Fondation de l'Hôpital général juif; Wellcome Trust","keywords":"Interim analysis; Medicine; Capecitabine; Brachytherapy; External beam radiotherapy; Interim; Radiation therapy; Randomized controlled trial; Colorectal cancer; External beam radiation; Surgery; Population; Nuclear medicine; Urology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005001259,0.001314429,0.001264647,0.0004299859,0.0003920618,0.0009373812,0.0007725158,0.001039524,0.004590032],"category_scores_gemma":[0.003049639,0.0003288368,0.001734065,0.0003379744,0.0008637021,0.0006335467,0.0004754898,0.001942319,0.0008649185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006268414,"about_ca_system_score_gemma":0.001758709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003253794,"about_ca_topic_score_gemma":0.0007058471,"domain_scores_codex":[0.9984855,0.001015469,0.00006072319,0.0001134797,0.0001394115,0.0001855089],"domain_scores_gemma":[0.998463,0.0003554442,0.0003908338,0.0002759769,0.0001414189,0.0003732574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8026699,0.03520981,0.01310947,0.0009881054,0.00201198,0.0002651321,0.0002471633,0.003130305,0.03331652,0.0008468569,0.00466338,0.1035414],"study_design_scores_gemma":[0.3555199,0.5971571,0.02117502,0.00009614146,0.001543518,0.0004453463,0.00007285132,0.001393026,0.0120163,0.0009441891,0.009596683,0.00003990705],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969061,0.00216423,0.006460877,0.0009953834,0.0002828589,0.01075575,0.004165542,0.0002642559,0.005849959],"genre_scores_gemma":[0.9550802,0.001330657,0.01464701,0.00209499,0.0003113511,0.01413062,0.006508722,0.0001536362,0.005742647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005001259,"threshold_uncertainty_score":0.0264495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505010550988886,"score_gpt":0.3357136916393382,"score_spread":0.3106635861294494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}