{"id":"W4288077431","doi":"10.3390/cancers14153665","title":"MORPHEUS Phase II–III Study: A Pre-Planned Interim Safety Analysis and Preliminary Results","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; McGill University; Jewish General Hospital","funders":"Fondation de l'Hôpital général juif; Wellcome Trust","keywords":"Interim analysis; Medicine; Capecitabine; Brachytherapy; External beam radiotherapy; Interim; Radiation therapy; Randomized controlled trial; Colorectal cancer; External beam radiation; Surgery; Population; Nuclear medicine; Urology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000225533,0.0001832338,0.0005056984,0.00020427,0.0003015418,0.00001115022,0.0001049292,0.00002991968,0.001072742],"category_scores_gemma":[0.00004773821,0.0001656366,0.0001383382,0.000954236,0.00006870784,0.00005053213,0.0003036786,0.0002160897,0.000001823229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002212926,"about_ca_system_score_gemma":0.0002841822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001833965,"about_ca_topic_score_gemma":0.0003095033,"domain_scores_codex":[0.9984279,0.00009822997,0.0003372354,0.0005266994,0.0003565852,0.0002532928],"domain_scores_gemma":[0.9991677,0.0000819807,0.0001160026,0.0003854014,0.00004177448,0.0002071129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7248199,0.005286668,0.05193157,0.0001118297,0.01537341,0.004339112,0.03455004,0.00613642,0.0007073678,0.00001181894,0.009904101,0.1468278],"study_design_scores_gemma":[0.1828381,0.3168269,0.3226282,0.0001880892,0.01835162,0.0003868182,0.02148389,0.02047668,0.001278869,0.00004729714,0.1139851,0.00150856],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937975,0.0007459231,0.00001958039,0.0003850329,0.0002076626,0.001027409,0.000417204,0.00007890559,0.003320713],"genre_scores_gemma":[0.9958746,0.00006835778,0.00004999931,0.0002242924,0.00005200279,0.000453581,0.0002097704,0.00001802969,0.003049375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5419818,"threshold_uncertainty_score":0.9998404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505010550988886,"score_gpt":0.3357136916393382,"score_spread":0.3106635861294494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}