{"id":"W4288078050","doi":"10.1016/j.bbagrm.2022.194845","title":"Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro","year":2022,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Genentech; Innovative Medicines Initiative; Kungliga Tekniska Högskolan; Ontario Genomics Institute; Janssen Pharmaceuticals; Merck KGaA; McGill University; Takeda Canada; Genome Canada; Boehringer Ingelheim; Pfizer; Bristol-Myers Squibb","keywords":"Nucleosome; Histone methylation; Histone; Histone methyltransferase; Acetylation; Biology; Histone code; Biochemistry; Chromatin; Cell biology; Chemistry; DNA; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006396817,0.0003964315,0.0003973305,0.000218702,0.0001951357,0.0005511118,0.0005137694,0.0002731877,0.002073015],"category_scores_gemma":[0.0007579076,0.0003789956,0.0002779401,0.0002591098,0.0002945659,0.0002156416,0.0003977781,0.0007449641,0.0006872552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003666705,"about_ca_system_score_gemma":0.0003605881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001637494,"about_ca_topic_score_gemma":0.003423174,"domain_scores_codex":[0.9995498,0.0001283442,0.00004496627,0.00009328785,0.00008372682,0.00009986215],"domain_scores_gemma":[0.9994106,0.0003292456,0.00005150621,0.00008005606,0.0000524325,0.00007621117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002463385,0.00003907266,0.0003483355,0.00003154649,0.00001713454,0.00002130202,0.00001549835,0.00006812378,0.9980639,0.00009572597,0.00003427495,0.001018798],"study_design_scores_gemma":[0.000008668517,0.00006661133,0.0008472672,0.000001937202,0.00001053659,0.00003754571,0.000005200255,0.0003335595,0.998174,0.00002024068,0.00049109,0.000003330318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857447,0.003862265,0.006491216,0.0001372713,0.0001295079,0.00002559768,0.0003481316,0.0001297926,0.003131616],"genre_scores_gemma":[0.9940685,0.00106109,0.001998,0.00004776328,0.0000233208,0.00001214663,0.001016565,0.00005646125,0.001716194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002073015,"threshold_uncertainty_score":0.006934941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071715195008593,"score_gpt":0.2682324145665593,"score_spread":0.2575152626164733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}