{"id":"W4288080559","doi":"10.1111/all.15456","title":"Dupilumab reduced impact of severe exacerbations on lung function in patients with moderate‐to‐severe type 2 asthma","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Sanofi Genzyme; Genentech; Grifols; AstraZeneca; Chiesi Farmaceutici; CSL Behring; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Patient-Centered Outcomes Research Institute; National Institutes of Health; Allergy Therapeutics; Shionogi; Sanofi; Mereo BioPharma; Vifor Pharma; Pfizer; Amgen","keywords":"Dupilumab; Medicine; Lung function; Asthma; Asthma exacerbations; Severity of illness; Lung; Intensive care medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008252669,0.0003538425,0.001104531,0.0001162431,0.0001700786,0.0005684951,0.0001925421,0.0003276815,0.002093481],"category_scores_gemma":[0.001341869,0.0001478613,0.001546001,0.0001489637,0.0001280479,0.0002350495,0.0002140659,0.0006801471,0.0001461934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003639965,"about_ca_system_score_gemma":0.0003871056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009965602,"about_ca_topic_score_gemma":0.003843365,"domain_scores_codex":[0.9994726,0.0002705866,0.00004169696,0.00007553981,0.00005611587,0.00008355509],"domain_scores_gemma":[0.9993107,0.0002829338,0.0001633547,0.00002922612,0.00005331954,0.0001604179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3153316,0.003725185,0.403038,0.003227823,0.01370119,0.0005022362,0.0001784403,0.001936381,0.01593631,0.0002449974,0.007443227,0.2347346],"study_design_scores_gemma":[0.02098559,0.04894585,0.913314,0.0002803993,0.00516237,0.0009469672,0.0001761678,0.003178506,0.002095833,0.0002047876,0.004656688,0.00005270346],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987408,0.01001869,0.0001113508,0.0002983949,0.00007875696,0.00008664199,0.0006151269,0.00001941138,0.001363571],"genre_scores_gemma":[0.9986111,0.0004878998,0.0001213615,0.0001934854,0.00005179594,0.00002909676,0.0002291326,0.000001629127,0.0002744681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002093481,"threshold_uncertainty_score":0.007003427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008425355632608916,"score_gpt":0.2486449790773829,"score_spread":0.240219623444774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}