{"id":"W4288080864","doi":"10.1038/s41598-022-17088-0","title":"The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Faculty of Health Sciences, Queen's University; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Queen's University; Fondation pour la Recherche Médicale; Canada Foundation for Innovation; National Institutes of Health; J.P. Bickell Foundation; Banting Research Foundation; McGill University","keywords":"Heparan sulfate; Coronavirus; Biology; Virology; Catechin; Virus; Coronavirus disease 2019 (COVID-19); Cell; Cell biology; Chemistry; Microbiology; Biochemistry; Polyphenol; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003289096,0.000744843,0.000305547,0.000232727,0.0002171157,0.0004572793,0.000482395,0.0008494896,0.003613329],"category_scores_gemma":[0.0001535877,0.0001751297,0.0005260141,0.0001677344,0.0001937995,0.0003769295,0.0002496054,0.001123018,0.0007653313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670223,"about_ca_system_score_gemma":0.0004784833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131005,"about_ca_topic_score_gemma":0.001742325,"domain_scores_codex":[0.999871,0.00001927776,0.000008033778,0.00002480757,0.0000412431,0.00003568476],"domain_scores_gemma":[0.9999387,0.000008355847,0.00001200473,0.000008000732,0.00001615517,0.00001666968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006948959,0.0003773725,0.0001637369,0.0003939774,0.00005389895,0.0002105622,0.00003146099,0.0004354094,0.9749459,0.0009222989,0.002797792,0.01897269],"study_design_scores_gemma":[0.0002285467,0.001955106,0.001225795,0.00003159582,0.0001026014,0.0004206122,0.00002151209,0.0008331451,0.9439683,0.0002087802,0.05098638,0.00001756276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8196707,0.04825523,0.07200992,0.007090739,0.002253019,0.001675604,0.007223978,0.002023123,0.03979763],"genre_scores_gemma":[0.9405953,0.01652421,0.02191074,0.001452083,0.0001209112,0.0003479889,0.003826849,0.0001326161,0.01508937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003613329,"threshold_uncertainty_score":0.01208776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07113641178694809,"score_gpt":0.4187709796630769,"score_spread":0.3476345678761288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}