{"id":"W4288096287","doi":"10.1038/s41434-022-00359-w","title":"rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis","year":2022,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Retinopathy; Retinal; Ceramide; Fundus (uterus); Biology; Ectopic expression; Electroretinography; Phenotype; Retina; Pathology; Medicine; Endocrinology; Gene; Ophthalmology; Biochemistry; Diabetes mellitus; Neuroscience; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101103,0.000141862,0.0003365455,0.0001113758,0.00003710611,0.000002964018,0.00009922114,0.00004151961,0.0001965351],"category_scores_gemma":[0.00001119885,0.0001173891,0.0001393686,0.0002022169,0.00003270552,0.00003423492,0.00006031843,0.00009718382,0.000001537216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000604251,"about_ca_system_score_gemma":0.00007664111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001084749,"about_ca_topic_score_gemma":6.253547e-7,"domain_scores_codex":[0.9987797,0.0001049171,0.0003307973,0.0002129681,0.0003933699,0.0001782103],"domain_scores_gemma":[0.9993533,0.00001686464,0.0001672819,0.0003344884,0.00003783367,0.0000901582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003508233,0.001881009,0.08456777,0.00004476305,0.00006602379,0.00001750967,0.0004448517,0.001435046,0.9062597,0.000005917671,0.0000665116,0.001702646],"study_design_scores_gemma":[0.01075408,0.001385509,0.03794854,0.00008331928,0.00005758191,0.000005368322,0.00009605949,0.008808138,0.9404331,0.000178058,0.00008587675,0.0001643484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969837,0.001870489,0.00004432987,0.00004252308,0.00003595784,0.0005720706,0.0003499432,0.00002059624,0.00008036829],"genre_scores_gemma":[0.9978315,0.001099006,0.0003458216,0.0001309355,0.00001094004,0.0001264651,0.0001611469,0.00002889707,0.0002653515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04661923,"threshold_uncertainty_score":0.4786987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830320587326075,"score_gpt":0.268740716852521,"score_spread":0.2504375109792603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}