{"id":"W4288435626","doi":"10.26685/urncst.363","title":"Sequencing and Detection of Two Missense Variants at Chromosome 7 as Potential Azole Resistance Markers in Saccharomyces Cerevisiae","year":2022,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto","keywords":"Biology; Genetics; Clotrimazole; Missense mutation; Azole; Saccharomyces cerevisiae; Gene; Antibiotic resistance; Phenotype; Drug resistance; Antifungal drug; Microbiology; Candida albicans; Antifungal; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119733,0.0003911434,0.0003269874,0.000608049,0.0002080356,0.0005571263,0.0003400816,0.0005640115,0.0005544678],"category_scores_gemma":[0.0006408381,0.0001525084,0.0005727801,0.0006698562,0.0001697592,0.000110197,0.0002360834,0.0003227195,0.0005488259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243961,"about_ca_system_score_gemma":0.0002692578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001881321,"about_ca_topic_score_gemma":0.003569091,"domain_scores_codex":[0.9997659,0.00002295506,0.00003678992,0.00007835406,0.00007484415,0.0000211191],"domain_scores_gemma":[0.9995671,0.0001230185,0.0001040565,0.00006936328,0.00009423165,0.00004229156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003194878,0.00005748369,0.01084072,0.0001424827,0.00008150336,0.002023037,0.0002544699,0.0006184395,0.9751273,0.0001351311,0.0001846882,0.01021524],"study_design_scores_gemma":[0.00005683804,0.0006040324,0.1489486,0.0001083859,0.0004665261,0.004922827,0.0008344399,0.006516011,0.8268437,0.0003777563,0.010236,0.00008483806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901327,0.0005784037,0.00509378,0.00006186596,0.00003277108,0.00004773761,0.003379175,0.0001880275,0.0004854301],"genre_scores_gemma":[0.9702334,0.0006893905,0.01716847,0.0001068018,0.0000122888,0.00004125131,0.01076888,0.0001248926,0.0008546863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881321,"threshold_uncertainty_score":0.003740728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02583817770378351,"score_gpt":0.3623326523471196,"score_spread":0.3364944746433361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}