{"id":"W4288439387","doi":"10.1371/journal.ppat.1010739","title":"Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/core genes","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; Technische Universität München; University of Pittsburgh","keywords":"Woodchuck hepatitis virus; Glycosylation; Virology; Hepatitis B virus; Biology; cccDNA; Gene; Heterologous; N-linked glycosylation; Virus; Genetics; Hepadnaviridae; HBsAg; Glycoprotein; Glycan","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000299882,0.0001541668,0.0004477443,0.0004201536,0.0000766013,0.000003180511,0.00006971956,0.00006775443,0.0001152465],"category_scores_gemma":[0.000141399,0.0001751849,0.00009204818,0.0005476717,0.00009499941,0.0001226469,0.00009052648,0.0001536657,0.000002789163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004930245,"about_ca_system_score_gemma":0.0001843927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00144404,"about_ca_topic_score_gemma":0.001750262,"domain_scores_codex":[0.9982246,0.0001468598,0.0006664782,0.0002746454,0.0004557426,0.0002317354],"domain_scores_gemma":[0.9992507,0.00008483884,0.0002753861,0.0001965105,0.0001540922,0.00003846772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002059258,0.0002817636,0.572215,0.000146291,0.00003561695,0.000030146,0.001971005,0.001727841,0.4207389,0.0003390273,0.000003294959,0.002305224],"study_design_scores_gemma":[0.00181706,0.000650192,0.9326243,0.0002378686,0.00008785616,0.00001693429,0.001611738,0.05148869,0.01097462,0.0002946514,0.00002303659,0.0001730067],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967525,0.001342695,0.0003988671,0.0000903331,0.0001176694,0.0006958376,0.0003038905,0.00003036634,0.0002678639],"genre_scores_gemma":[0.9977801,0.0001328833,0.001668685,0.00002732561,0.00006817126,0.0001271583,0.0001530423,0.00002127913,0.00002137456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4097643,"threshold_uncertainty_score":0.7143834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692083612063572,"score_gpt":0.260574484952897,"score_spread":0.2236536488322612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}