{"id":"W4288442480","doi":"10.1038/s41598-022-17200-4","title":"Prime editor-mediated correction of a pathogenic mutation in purebred dogs","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Rural Development Administration","keywords":"Purebred; Prime (order theory); Mutation; Virology; Medicine; Genetics; Biology; Gene; Mathematics; Combinatorics; Crossbreed","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007383786,0.0002969053,0.0004860218,0.0006407611,0.0002890688,0.0005413812,0.0004208325,0.0008630876,0.00265167],"category_scores_gemma":[0.0006120895,0.0002456747,0.0003519073,0.0001975541,0.0005183277,0.0002554067,0.0005314261,0.00083671,0.000500405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039671,"about_ca_system_score_gemma":0.0002752445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004229883,"about_ca_topic_score_gemma":0.00093855,"domain_scores_codex":[0.9991959,0.0000949617,0.00007426511,0.0002981096,0.0002444011,0.00009240838],"domain_scores_gemma":[0.9995281,0.0001334369,0.000128547,0.00008282268,0.00005355406,0.00007364675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002165119,0.00006763222,0.0009482684,0.0001220859,0.00002634311,0.001169475,0.0001344027,0.0001720644,0.9879239,0.0007823371,0.0004348382,0.008002205],"study_design_scores_gemma":[0.00009762234,0.00116886,0.01039338,0.00004094403,0.0001454478,0.009063101,0.0001886183,0.003544325,0.9275724,0.0003833358,0.04736353,0.00003840636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942503,0.001327248,0.04718945,0.0004173253,0.0003238023,0.0003773425,0.001881409,0.001041634,0.004938715],"genre_scores_gemma":[0.9624069,0.0009416483,0.02156812,0.0003448763,0.00004891157,0.0001982699,0.002162026,0.0002951856,0.01203403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265167,"threshold_uncertainty_score":0.008870721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003777221936423837,"score_gpt":0.2467690605871432,"score_spread":0.2429918386507194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}