{"id":"W4288442698","doi":"10.1038/s44160-022-00109-1","title":"Enantioselective synthesis of γ-butenolides through Pd-catalysed C5-selective allylation of siloxyfurans","year":2022,"lang":"en","type":"article","venue":"Nature Synthesis","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Enantioselective synthesis; Tsuji–Trost reaction; Chemistry; Allylic rearrangement; Combinatorial chemistry; Desymmetrization; Alkylation; Selectivity; Stereoselectivity; Moiety; Stereochemistry; Substituent; Nucleophile; Steric effects; Palladium; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002104568,0.0006731681,0.0002726962,0.0003657115,0.0002665033,0.000391296,0.0004450856,0.0003046975,0.003295951],"category_scores_gemma":[0.0001507463,0.0001857974,0.0002567786,0.0003335407,0.0002821955,0.0004983473,0.0005097564,0.0007708857,0.001181702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005568537,"about_ca_system_score_gemma":0.0005737823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009466016,"about_ca_topic_score_gemma":0.002083713,"domain_scores_codex":[0.999841,0.00001523923,0.00001214868,0.00002353744,0.00002981225,0.0000782477],"domain_scores_gemma":[0.9999492,0.000007544423,0.00001025121,0.000008994333,0.000008370306,0.00001562785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003373973,0.000124747,0.0003190963,0.0003105511,0.00003480903,0.0009699173,0.0002881616,0.002125718,0.9636635,0.01051651,0.0008074362,0.0205021],"study_design_scores_gemma":[0.00002772131,0.0001286749,0.0003537533,0.00001495295,0.00001117129,0.0001217063,0.00004133549,0.0008608019,0.9911012,0.0004784461,0.006850193,0.000009932844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9275498,0.002393928,0.02019847,0.0004591101,0.0002186605,0.0002066764,0.001174614,0.0003375126,0.04746113],"genre_scores_gemma":[0.9894107,0.001478654,0.003663355,0.00006073739,0.00001341539,0.00002699694,0.0002787799,0.00004493473,0.005022408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003295951,"threshold_uncertainty_score":0.01102608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006791399052529267,"score_gpt":0.2340432408047664,"score_spread":0.2272518417522371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}