{"id":"W4288442698","doi":"10.1038/s44160-022-00109-1","title":"Enantioselective synthesis of γ-butenolides through Pd-catalysed C5-selective allylation of siloxyfurans","year":2022,"lang":"en","type":"article","venue":"Nature Synthesis","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Enantioselective synthesis; Tsuji–Trost reaction; Chemistry; Allylic rearrangement; Combinatorial chemistry; Desymmetrization; Alkylation; Selectivity; Stereoselectivity; Moiety; Stereochemistry; Substituent; Nucleophile; Steric effects; Palladium; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006678109,0.0004354114,0.001098724,0.0004936345,0.0003640113,0.0000184517,0.0008460102,0.0004749741,0.001699664],"category_scores_gemma":[0.00399196,0.0004171294,0.0007517583,0.00217789,0.0001908614,0.0002480987,0.0002058653,0.0008226045,0.000009256953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003451149,"about_ca_system_score_gemma":0.000209073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004316104,"about_ca_topic_score_gemma":0.00002429655,"domain_scores_codex":[0.9964129,0.000244719,0.0008801418,0.0007639633,0.001210639,0.0004875813],"domain_scores_gemma":[0.9936676,0.003982929,0.000995892,0.00084747,0.000426168,0.00007992769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001408814,0.002371976,0.009125391,0.0008377292,0.005350987,0.00002809024,0.004261087,0.0006700088,0.707653,0.003080918,0.002585829,0.2626261],"study_design_scores_gemma":[0.0002243371,0.00004383261,0.002267062,0.00008908098,0.0009010954,0.00001440039,0.002890933,0.0001585496,0.990517,0.0007487913,0.001722552,0.0004223958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7267152,0.008827826,0.001203711,0.0008863431,0.0004125063,0.0007285486,0.002925388,0.0003983213,0.2579021],"genre_scores_gemma":[0.9977415,0.0001524631,0.001216034,0.00004038958,0.0001064481,0.000324185,0.00005176288,0.00008294407,0.0002842278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2828639,"threshold_uncertainty_score":0.999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006791399052529267,"score_gpt":0.2340432408047664,"score_spread":0.2272518417522371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}