{"id":"W4288447073","doi":"10.3390/cancers14153684","title":"IKKε Inhibitor Amlexanox Promotes Olaparib Sensitivity through the C/EBP-β-Mediated Transcription of Rad51 in Castrate-Resistant Prostate Cancer","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Urological Oncology Group","keywords":"Olaparib; Cancer research; PARP inhibitor; Prostate cancer; DNA damage; RAD51; Biology; Cell growth; Poly ADP ribose polymerase; Cancer; DNA; Polymerase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009882641,0.0003231585,0.0003879522,0.0002400226,0.00012591,0.0003047391,0.0002079186,0.000181295,0.001315832],"category_scores_gemma":[0.00008353125,0.0001412137,0.0003022112,0.0001702147,0.0001646856,0.0001725757,0.0001290947,0.0008612411,0.0003250513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844812,"about_ca_system_score_gemma":0.0002170836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005731403,"about_ca_topic_score_gemma":0.0007394912,"domain_scores_codex":[0.9998829,0.00001872606,0.00001586984,0.00002271904,0.00002770919,0.00003208613],"domain_scores_gemma":[0.9999359,0.000009946082,0.00001507641,0.000009304843,0.000005588848,0.00002431573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008322377,0.0003085056,0.0003253754,0.00008795712,0.00001653898,0.00008017391,0.00003089432,0.0002247785,0.9939096,0.00008152769,0.0001789622,0.003923503],"study_design_scores_gemma":[0.0001156504,0.002036552,0.005547375,0.00000910686,0.00003311845,0.0002585805,0.00003950905,0.001390069,0.9885327,0.00004589472,0.001983841,0.000007675031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954396,0.001838062,0.0008058874,0.0001165549,0.0000551536,0.0000344512,0.0002962636,0.0001269322,0.001287104],"genre_scores_gemma":[0.9961282,0.0010403,0.0006029409,0.00006537135,0.0000109285,0.0000408729,0.0004309826,0.00001130887,0.001669049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315832,"threshold_uncertainty_score":0.004401922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02821694291268772,"score_gpt":0.2943153001869732,"score_spread":0.2660983572742854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}