{"id":"W4288447594","doi":"10.3390/biom12081045","title":"The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization","year":2022,"lang":"en","type":"review","venue":"Biomolecules","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Chaperone (clinical); Spliceosome; Hsp90; Biology; Cell biology; RNA polymerase II; Co-chaperone; snRNP; Transcription (linguistics); Transcription preinitiation complex; Multiprotein complex; Protein subunit; Genetics; Computational biology; RNA; Ribonucleoprotein; RNA splicing; Heat shock protein; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005946953,0.0002923309,0.0005611544,0.000153058,0.0001460966,0.00004749699,0.0005224683,0.0002450642,0.00003493922],"category_scores_gemma":[0.0002957161,0.0002277421,0.0001948384,0.0003821318,0.0002705106,0.000002367021,0.0006844187,0.0002170471,0.000003496356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005564333,"about_ca_system_score_gemma":0.0003618226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001059402,"about_ca_topic_score_gemma":0.0001238723,"domain_scores_codex":[0.9975616,0.0006944063,0.0005317064,0.0005138215,0.0003342165,0.0003642825],"domain_scores_gemma":[0.9989691,0.00008092647,0.0001805972,0.0006366589,0.00005373632,0.00007891476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002167216,0.00007138996,0.00001943512,0.001548762,0.00009605387,0.00001478895,0.00001777325,8.78548e-7,0.05727732,0.000541348,0.0000914226,0.9402992],"study_design_scores_gemma":[0.0001409737,0.000174894,0.00001000067,0.0002378018,0.00003655811,0.000029302,0.00006730034,0.00002501514,0.006608346,0.00005627611,0.9923888,0.0002247253],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009122527,0.9970952,0.0001078151,0.00002345228,0.00003104871,0.0009585039,0.00009354413,0.000007076755,0.0007710681],"genre_scores_gemma":[0.002399922,0.9964459,0.0001576036,0.00001112447,0.00003899895,0.0002765379,0.0005309651,0.00006477514,0.00007416053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9922974,"threshold_uncertainty_score":0.9287054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04165439788650074,"score_gpt":0.3494275290402981,"score_spread":0.3077731311537973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}