{"id":"W4288459194","doi":"10.1136/rmdopen-2022-002280","title":"Upadacitinib in active ankylosing spondylitis: results of the 2-year, double-blind, placebo-controlled SELECT-AXIS 1 study and open-label extension","year":2022,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"UCB Pharma; Astellas Pharma; Eisai; Chugai Pharmaceutical; Celltrion; AbbVie; Celgene; Gilead Sciences; Daiichi-Sankyo; Amgen; Pfizer; Eli Lilly and Company; GlaxoSmithKline","keywords":"Medicine; Ankylosing spondylitis; Placebo; Adverse effect; Internal medicine; Regimen; Spondylitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009377797,0.0002019194,0.0008174318,0.0001108085,0.000472039,0.00008433009,0.0004278298,0.00004077581,0.0002272482],"category_scores_gemma":[0.0001806732,0.0001449385,0.00004779873,0.0005374485,0.00006497292,0.0001929458,0.002055187,0.0002984989,0.000004240683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729165,"about_ca_system_score_gemma":0.0001636258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003762146,"about_ca_topic_score_gemma":0.001418513,"domain_scores_codex":[0.9979498,0.0003275248,0.0005006382,0.0005315802,0.0003955619,0.0002949366],"domain_scores_gemma":[0.9988878,0.0002034016,0.0002375831,0.0004876133,0.0001088279,0.00007473395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9473854,0.005876902,0.02667625,0.00002892615,0.0007798775,0.0004300397,0.007463541,0.00001071607,0.0007140244,0.000128817,0.001485654,0.009019821],"study_design_scores_gemma":[0.9081422,0.00430447,0.06558097,0.0002292643,0.0002930881,0.0001007361,0.01578757,0.0000644505,0.0005716723,0.00009602837,0.004603006,0.0002265329],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752994,0.0006178099,2.054992e-7,0.0008893747,0.000138062,0.009697974,0.0002951024,0.00001136823,0.01305066],"genre_scores_gemma":[0.9959139,0.00005635492,0.0001131715,0.0001853987,0.00002402218,0.0009285578,0.00006274237,0.00002620757,0.002689691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03924322,"threshold_uncertainty_score":0.5910422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07474983970830239,"score_gpt":0.3592303304791003,"score_spread":0.2844804907707979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}