{"id":"W4288459194","doi":"10.1136/rmdopen-2022-002280","title":"Upadacitinib in active ankylosing spondylitis: results of the 2-year, double-blind, placebo-controlled SELECT-AXIS 1 study and open-label extension","year":2022,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"UCB Pharma; Astellas Pharma; Eisai; Chugai Pharmaceutical; Celltrion; AbbVie; Celgene; Gilead Sciences; Daiichi-Sankyo; Amgen; Pfizer; Eli Lilly and Company; GlaxoSmithKline","keywords":"Medicine; Ankylosing spondylitis; Placebo; Adverse effect; Internal medicine; Regimen; Spondylitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004433834,0.001384646,0.002183151,0.0004395852,0.0003612772,0.001014795,0.0006209373,0.001178041,0.002598077],"category_scores_gemma":[0.001991114,0.000494575,0.001654237,0.0005356919,0.0008648752,0.0008383001,0.0003196382,0.001558652,0.0004415948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000727636,"about_ca_system_score_gemma":0.0009865857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109213,"about_ca_topic_score_gemma":0.002337747,"domain_scores_codex":[0.9987817,0.0006860406,0.00008401389,0.0001327356,0.0001624022,0.0001530522],"domain_scores_gemma":[0.9974142,0.000533591,0.0009181413,0.0001971081,0.0003019542,0.0006348544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9485285,0.007850523,0.00514833,0.0009341434,0.002177531,0.00009918295,0.0001632044,0.0004923615,0.005988618,0.00005817496,0.00123948,0.02731988],"study_design_scores_gemma":[0.7560874,0.1932441,0.04458773,0.00008320355,0.002406638,0.000201035,0.00007369753,0.0005555279,0.001347693,0.00006941973,0.001299362,0.00004413912],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907861,0.005305422,0.0003122766,0.0002160914,0.00009317216,0.001021289,0.001475745,0.0000548774,0.0007351011],"genre_scores_gemma":[0.9929878,0.002475341,0.0005863733,0.0002638096,0.0002380791,0.0007657603,0.001847042,0.00001502321,0.000820811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004433834,"threshold_uncertainty_score":0.02344865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07474983970830239,"score_gpt":0.3592303304791003,"score_spread":0.2844804907707979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}