{"id":"W4288490422","doi":"10.1177/13524585221110585","title":"Permanent tissue damage in multiple sclerosis lesions is associated with reduced pre-lesion myelin and axon volume fractions","year":2022,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Polytechnique Montréal; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Novartis Pharmaceuticals Canada; Natural Sciences and Engineering Research Council of Canada; Mitacs; Myelin Repair Foundation","keywords":"Multiple sclerosis; Myelin; Axon; Lesion; Pathology; Myelin sheath; Medicine; Anatomy; Central nervous system; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003960934,0.0002156338,0.000241664,0.0006665832,0.00025436,0.0003597466,0.0001721819,0.0003618354,0.001922119],"category_scores_gemma":[0.001556586,0.0001291347,0.0001376035,0.0003844661,0.0002989518,0.0003731014,0.0002893881,0.0003981674,0.0002894094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614095,"about_ca_system_score_gemma":0.0001353335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006757424,"about_ca_topic_score_gemma":0.0008951537,"domain_scores_codex":[0.9998831,0.00001662197,0.00001445938,0.00003445608,0.00002983054,0.00002162122],"domain_scores_gemma":[0.9979739,0.0002002368,0.001300886,0.00009552666,0.000186979,0.0002424645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001513483,0.0001856808,0.9597865,0.00007950006,0.0001085847,0.0005026277,0.0002604274,0.0001342916,0.02437108,0.00003422129,0.0001110483,0.01291248],"study_design_scores_gemma":[0.000002647191,0.0002539387,0.9978822,0.000003551415,0.0000128817,0.0008507872,0.0000379995,0.00004831682,0.0008216153,0.00002997151,0.00005416973,0.00000204914],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994978,0.0001977177,0.00007952398,0.00001083515,0.000001994656,0.000002452388,0.00003991439,0.000005209828,0.0001645602],"genre_scores_gemma":[0.9996582,0.00006566924,0.00008774963,0.000003324363,0.000004665757,0.000002101748,0.00006591149,0.000001702824,0.000110757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922119,"threshold_uncertainty_score":0.006430149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1284733295812451,"score_gpt":0.3127205270181618,"score_spread":0.1842471974369166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}