{"id":"W4288515081","doi":"10.1002/acn3.51626","title":"Amyloidogenicity assessment of transthyretin gene variants","year":2022,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"Deutsche Forschungsgemeinschaft; Alnylam Pharmaceuticals","keywords":"Medicine; Transthyretin; Gene; Computational biology; Bioinformatics; MEDLINE; Genetics; Pathology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006457751,0.000637852,0.000233557,0.0005870644,0.0001701782,0.0003484871,0.0001939606,0.0004189874,0.0006903246],"category_scores_gemma":[0.0008492942,0.0001408699,0.0004736238,0.0003043558,0.0002707292,0.000170341,0.00028619,0.0003345097,0.0002352497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942098,"about_ca_system_score_gemma":0.0001007678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000611342,"about_ca_topic_score_gemma":0.0004715221,"domain_scores_codex":[0.9993852,0.0001702287,0.0000571611,0.0001226813,0.0002234439,0.00004119017],"domain_scores_gemma":[0.9993504,0.0002205123,0.0001525486,0.0000655962,0.000160233,0.00005068422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009341804,0.00001808898,0.004075559,0.00004896373,0.00002095512,0.0001329271,0.00004114106,0.0003029358,0.9943789,0.00002025073,0.00000887823,0.0008581118],"study_design_scores_gemma":[0.000006238649,0.0005566528,0.01952686,0.00001233177,0.00007050104,0.001337918,0.0000523329,0.001856701,0.9760064,0.0000493494,0.0005137424,0.00001093167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944808,0.0007347776,0.004077333,0.00001486841,0.000008047757,0.00001964736,0.0002186578,0.0000340163,0.0004118473],"genre_scores_gemma":[0.9962078,0.0003161645,0.00275594,0.00001077315,0.000003547648,0.00001096976,0.0004094185,0.00000982749,0.000275465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006903246,"threshold_uncertainty_score":0.003415227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08030992578260913,"score_gpt":0.4031206332285012,"score_spread":0.322810707445892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}