{"id":"W4288697520","doi":"10.1080/19490976.2022.2105095","title":"Gut bacteria interact directly with colonic mast cells in a humanized mouse model of IBS","year":2022,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McMaster University; Population Health Research Institute","funders":"","keywords":"Degranulation; Irritable bowel syndrome; Lamina propria; Biology; Immunology; Gut flora; Mast cell; Histamine; Chemotaxis; TLR4; Pathogenesis; Interleukin 33; Microbiology; Inflammation; Receptor; Cytokine; Medicine; Interleukin; Epithelium; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001495798,0.0001496665,0.0003441687,0.0001542502,0.00005627827,0.00001090686,0.0001358049,0.00002478011,0.0005672035],"category_scores_gemma":[0.00003449457,0.0001367729,0.00007145129,0.000168237,0.00008214194,0.0000576557,0.0001258847,0.0002699241,0.00001180873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000100317,"about_ca_system_score_gemma":0.0001370456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000344818,"about_ca_topic_score_gemma":0.0005015158,"domain_scores_codex":[0.9990097,0.0000655781,0.000287853,0.0002499814,0.0001410189,0.0002458739],"domain_scores_gemma":[0.9994873,0.00004460079,0.0001005654,0.0002547994,0.00005367442,0.00005902099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001571787,0.0006406104,0.007679788,0.0001289221,0.00002540073,0.0000218906,0.00126185,0.00115524,0.9867856,0.00001861647,0.0005798743,0.0001304429],"study_design_scores_gemma":[0.05630871,0.01684972,0.1937849,0.002477051,0.0008807656,0.001226062,0.01828297,0.03898555,0.6584592,0.0007215774,0.009679014,0.002344437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983947,0.00006333438,0.0001222313,0.0002799046,0.00003723839,0.0003553754,0.00008149441,0.0000370079,0.0006287409],"genre_scores_gemma":[0.9937317,0.00000766471,0.003971872,0.0002391541,0.000008562825,0.00003240718,0.00004225429,0.00002494258,0.001941468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3283263,"threshold_uncertainty_score":0.621048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464107641242455,"score_gpt":0.2274186253095146,"score_spread":0.2127775488970901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}