{"id":"W4288708392","doi":"10.1038/s41386-022-01384-4","title":"In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure – a multimodal imaging study with PET, 1H-MRS, and MRI","year":2022,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute; Université de Montréal; Centre for Addiction and Mental Health; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; Canada Research Chairs; U.S. Department of Health and Human Services; Government of Canada; National Alliance for Research on Schizophrenia and Depression","keywords":"Hippocampal formation; Hippocampus; Fatty acid amide hydrolase; Internal medicine; Endocannabinoid system; Glutamate receptor; Glutamatergic; Anandamide; Endocrinology; Neuroscience; Psychosis; Psychology; Medicine; Cannabinoid receptor; Psychiatry; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002529588,0.0004437019,0.0003256339,0.0003935643,0.0004392249,0.0004255108,0.0003969033,0.0005845348,0.002356385],"category_scores_gemma":[0.000228236,0.0004671655,0.0002744931,0.0005540929,0.001048999,0.0009267207,0.0002101661,0.0006707851,0.000390906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979603,"about_ca_system_score_gemma":0.0003270304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003419687,"about_ca_topic_score_gemma":0.00426326,"domain_scores_codex":[0.9999384,0.00001157164,0.000003392701,0.00002138192,0.000009491465,0.00001581646],"domain_scores_gemma":[0.9999312,0.00001037077,0.00001888685,0.00001371296,0.00001170188,0.00001421852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007408807,0.0003978054,0.004149924,0.0001035099,0.0001289251,0.0004228089,0.0001912296,0.0001673193,0.9773604,0.0003448145,0.0001350796,0.009189368],"study_design_scores_gemma":[0.0008002971,0.005488965,0.2602351,0.00003066258,0.0007514061,0.006928323,0.0009626995,0.005170536,0.7127233,0.002065434,0.004743117,0.0001001976],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933495,0.001928063,0.002821679,0.0001365512,0.00002242161,0.00004648024,0.0001943572,0.00001821672,0.001482734],"genre_scores_gemma":[0.9896362,0.002358224,0.003486641,0.0000902863,0.0000394041,0.00008758145,0.0003075321,0.00004932752,0.003944825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003419687,"threshold_uncertainty_score":0.007882893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004873783584757988,"score_gpt":0.2987833549065894,"score_spread":0.2939095713218314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}