{"id":"W4288827565","doi":"10.1016/j.ebiom.2022.104203","title":"Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biomedical Advanced Research and Development Authority; Merck Sharp and Dohme; Defense Threat Reduction Agency; Public Health Agency of Canada; International AIDS Vaccine Initiative; U.S. Department of Health and Human Services; Merck; U.S. Department of Defense","keywords":"Virology; Vesicular stomatitis virus; Immunogenicity; Vaccination; Viral shedding; Virus; Vesicular stomatitis Indiana virus; Medicine; Nasal administration; DNA vaccination; Immunity; Coronavirus; Biology; Immunology; Immune system; Immunization; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00103756,0.0002043445,0.0005979989,0.0005042792,0.0002980071,0.00001001859,0.0001333292,0.00007297774,0.0009850665],"category_scores_gemma":[0.0006583004,0.0001635311,0.0001460142,0.0007983903,0.0002025759,0.0000359736,0.0001694766,0.0005296142,0.00001405845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110082,"about_ca_system_score_gemma":0.0004027937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002832446,"about_ca_topic_score_gemma":0.00006457757,"domain_scores_codex":[0.9977613,0.0002443028,0.0005483496,0.0004171676,0.0006992722,0.0003295806],"domain_scores_gemma":[0.9986034,0.0003862118,0.0001487701,0.0005014957,0.00007783073,0.000282317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01095556,0.004293086,0.0241868,0.000737024,0.0007228343,0.0008777876,0.0008238975,0.0001850196,0.9019866,0.0001368453,0.03583376,0.01926076],"study_design_scores_gemma":[0.09459449,0.04116138,0.3815401,0.0006058993,0.001183363,0.001445889,0.0003741764,0.04147759,0.1646703,0.0001672003,0.27174,0.001039623],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881644,0.0007423926,0.0004811162,0.008818833,0.00017896,0.0008522418,0.0001503965,0.00008271435,0.0005288926],"genre_scores_gemma":[0.9933725,0.0001059094,0.0001590569,0.005719044,0.0001610848,0.00007996577,0.0001941432,0.0000297737,0.0001784938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7373163,"threshold_uncertainty_score":0.9999282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04331429342542391,"score_gpt":0.3875994907603331,"score_spread":0.3442851973349091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}