{"id":"W4288827565","doi":"10.1016/j.ebiom.2022.104203","title":"Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biomedical Advanced Research and Development Authority; Merck Sharp and Dohme; Defense Threat Reduction Agency; Public Health Agency of Canada; International AIDS Vaccine Initiative; U.S. Department of Health and Human Services; Merck; U.S. Department of Defense","keywords":"Virology; Vesicular stomatitis virus; Immunogenicity; Vaccination; Viral shedding; Virus; Vesicular stomatitis Indiana virus; Medicine; Nasal administration; DNA vaccination; Immunity; Coronavirus; Biology; Immunology; Immune system; Immunization; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004945457,0.0006352579,0.0003616195,0.0002838663,0.0001547355,0.0002628022,0.0003015892,0.000486859,0.001312513],"category_scores_gemma":[0.0002479136,0.0001758455,0.0003370865,0.0001271425,0.0003088936,0.0003734307,0.0001380881,0.001127787,0.0003098492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004784238,"about_ca_system_score_gemma":0.0004701304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005733097,"about_ca_topic_score_gemma":0.0003641121,"domain_scores_codex":[0.9998119,0.00003050844,0.00001732136,0.00003100565,0.00003759212,0.00007176117],"domain_scores_gemma":[0.999777,0.00003463609,0.00005666042,0.00002377216,0.00004277577,0.00006515109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004215684,0.004040113,0.0006855393,0.00009873007,0.00003724263,0.00006071849,0.00004231778,0.0009267299,0.9867813,0.0001300611,0.0001579704,0.002823644],"study_design_scores_gemma":[0.001030488,0.09573743,0.005596379,0.00002411924,0.0001292308,0.0002727331,0.00004940529,0.002913337,0.8923334,0.0001071197,0.00179203,0.00001428815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980996,0.0002526009,0.0006591642,0.00003498747,0.00003522749,0.00012397,0.0003239231,0.0000284626,0.0004420853],"genre_scores_gemma":[0.9967812,0.0002965679,0.0007217762,0.00004552486,0.0000175567,0.0001331083,0.00106884,0.000009937612,0.000925419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312513,"threshold_uncertainty_score":0.004390836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04331429342542391,"score_gpt":0.3875994907603331,"score_spread":0.3442851973349091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}