{"id":"W4288843991","doi":"10.1001/jamaneurol.2022.2379","title":"Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Centre Hospitalier de l’Université de Montréal; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging","keywords":"Dementia; Biomarker; Cognitive decline; Cohort; Positron emission tomography; Clinical Dementia Rating; Medicine; Population; Internal medicine; Alzheimer's disease; Disease; Cohort study; Psychology; Oncology; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003965437,0.0001537161,0.0003209436,0.0002815284,0.0000953073,0.000009128154,0.00005938462,0.00006980359,0.0002633061],"category_scores_gemma":[0.0000356543,0.0001312482,0.00005049992,0.0003481491,0.00009962156,0.00006274713,0.0001399009,0.0003805024,8.916462e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004386085,"about_ca_system_score_gemma":0.0002572378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002433577,"about_ca_topic_score_gemma":0.000007419962,"domain_scores_codex":[0.9980294,0.0003259764,0.0003682248,0.0003437685,0.0006061359,0.0003264796],"domain_scores_gemma":[0.9991748,0.0001051557,0.0002434695,0.00009326737,0.0002219722,0.000161389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01462176,0.001308066,0.9681073,0.00009687316,0.0002912435,0.0001006021,0.001234355,0.000002501882,0.00597457,0.000001133008,0.00004374868,0.008217846],"study_design_scores_gemma":[0.01031896,0.004020521,0.9732828,0.0001391069,0.0002667723,0.00002004057,0.0001820762,0.0003002286,0.01132596,0.000004942878,0.00003040478,0.0001082046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978315,0.000171315,0.00002006622,0.0006919684,0.00002360804,0.001141633,0.00003028539,0.00001561459,0.00007403866],"genre_scores_gemma":[0.9990764,0.00001072859,0.00004959294,0.0004373764,0.00001385672,0.0002024065,0.0001357672,0.00001847479,0.00005543437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008109642,"threshold_uncertainty_score":0.5352146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005696008147228447,"score_gpt":0.2535488971953923,"score_spread":0.2478528890481638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}