{"id":"W4288843991","doi":"10.1001/jamaneurol.2022.2379","title":"Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Centre Hospitalier de l’Université de Montréal; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging","keywords":"Dementia; Biomarker; Cognitive decline; Cohort; Positron emission tomography; Clinical Dementia Rating; Medicine; Population; Internal medicine; Alzheimer's disease; Disease; Cohort study; Psychology; Oncology; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009363645,0.0003484348,0.000286359,0.0006659181,0.0004199849,0.0005129089,0.0003729684,0.0005345275,0.0009426075],"category_scores_gemma":[0.003821259,0.0002385281,0.0003322965,0.0006723795,0.0002852331,0.0004488972,0.000433035,0.0005626276,0.000173191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622046,"about_ca_system_score_gemma":0.0002754999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003121056,"about_ca_topic_score_gemma":0.006319102,"domain_scores_codex":[0.9996294,0.00009619237,0.00006087566,0.0001059874,0.00006748507,0.00004007719],"domain_scores_gemma":[0.9973235,0.0003897948,0.001382401,0.0002083314,0.0003346774,0.0003613266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002050987,0.00002314611,0.9989653,0.000006470704,0.00003704266,0.00006020013,0.00001833362,0.00001305608,0.0001356141,0.000005119822,0.00003081909,0.0004997987],"study_design_scores_gemma":[0.000007730064,0.0001122639,0.9994242,0.000002669259,0.00002520251,0.0002376376,0.00002877057,0.00006657034,0.00003418652,0.00001623946,0.00004279196,0.000001808734],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990022,0.0003232922,0.00007157652,0.00003515127,0.000008023351,0.00000583909,0.0002867673,0.000002988792,0.0002643206],"genre_scores_gemma":[0.9994035,0.00008326089,0.00009355009,0.00002040995,0.00001489995,0.000005433737,0.0002783317,9.056685e-7,0.00009982792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003121056,"threshold_uncertainty_score":0.006205738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005696008147228447,"score_gpt":0.2535488971953923,"score_spread":0.2478528890481638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}