{"id":"W4288886227","doi":"10.1016/j.bpsgos.2022.07.003","title":"Daily Δ9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry Global Open Science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Anxiogenic; Dynorphin; Anhedonia; κ-opioid receptor; Dopamine; Pharmacology; Dopamine receptor D2; Opioid; Medicine; Neuroscience; Chemistry; Receptor; Psychology; Internal medicine; Opioid peptide; Anxiolytic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000051708,0.0003070596,0.000226798,0.0002248173,0.0001652579,0.0001793406,0.0001573399,0.0002146658,0.001827302],"category_scores_gemma":[0.00009125012,0.0001599783,0.0002286143,0.0001019839,0.0002719064,0.000149489,0.0001520372,0.000578846,0.0002707431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004212744,"about_ca_system_score_gemma":0.0003692765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002934853,"about_ca_topic_score_gemma":0.009103484,"domain_scores_codex":[0.9999158,0.000007396673,0.000005563768,0.0000163101,0.00002804898,0.00002680831],"domain_scores_gemma":[0.9999288,0.000005258007,0.00001799206,0.000006736802,0.00001000663,0.0000311546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004869693,0.0001110256,0.0003010526,0.00003034446,0.000008578932,0.00005900058,0.00001576899,0.00002072856,0.9970523,0.00004459186,0.00004278492,0.001826775],"study_design_scores_gemma":[0.0001346187,0.003512658,0.04635145,0.00001596014,0.00005477388,0.0005304198,0.0001425543,0.0009925313,0.9452868,0.0001960815,0.002761246,0.00002091399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978255,0.0006661256,0.0004422023,0.00006354733,0.0000202033,0.00001802769,0.0002085919,0.00003249105,0.0007232953],"genre_scores_gemma":[0.994391,0.0007803522,0.0006372692,0.0000632858,0.000009354019,0.00004101866,0.0002708536,0.0000093799,0.003797436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002934853,"threshold_uncertainty_score":0.006112933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207855440337122,"score_gpt":0.3193663924559551,"score_spread":0.2972878380525839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}