{"id":"W4288886227","doi":"10.1016/j.bpsgos.2022.07.003","title":"Daily Δ9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry Global Open Science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Anxiogenic; Dynorphin; Anhedonia; κ-opioid receptor; Dopamine; Pharmacology; Dopamine receptor D2; Opioid; Medicine; Neuroscience; Chemistry; Receptor; Psychology; Internal medicine; Opioid peptide; Anxiolytic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001601291,0.0004462871,0.0006708905,0.0001585277,0.001143666,0.0004138278,0.001198691,0.0001610635,0.0006236725],"category_scores_gemma":[0.0002502586,0.0003338058,0.00008708105,0.001663938,0.001414357,0.0004243188,0.003789846,0.0004812266,0.00002628044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003047063,"about_ca_system_score_gemma":0.0007198875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001760179,"about_ca_topic_score_gemma":0.0001712818,"domain_scores_codex":[0.9953426,0.0002239173,0.0005375707,0.001810486,0.001070165,0.001015334],"domain_scores_gemma":[0.9976845,0.00002033679,0.0001533814,0.0006150113,0.0001751592,0.001351586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00565816,0.002728877,0.6226348,0.0001724873,0.0001271607,0.0002426085,0.0009066632,0.000003312509,0.2455727,0.01266073,0.08407079,0.02522164],"study_design_scores_gemma":[0.0105078,0.02095888,0.7221906,0.0001589114,0.0002125872,0.003117857,0.004947623,0.0001584091,0.00148812,0.003844227,0.2302014,0.002213574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786036,0.001682159,0.00002584421,0.01520554,0.0009724409,0.002354942,0.0006366197,0.00006638635,0.0004524966],"genre_scores_gemma":[0.986085,0.0004030051,0.006183811,0.00553939,0.0001926996,0.0006883022,0.00006691844,0.0000249348,0.0008159666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2440846,"threshold_uncertainty_score":0.9999114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207855440337122,"score_gpt":0.3193663924559551,"score_spread":0.2972878380525839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}