{"id":"W4288925172","doi":"10.1101/2022.07.29.501749","title":"PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Dalhousie University","funders":"","keywords":"Retrotransposon; Biology; Promyelocytic leukemia protein; Cytoplasm; Genetics; Cell biology; Nuclear protein; Gene; Genome; Transcription factor; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346084,0.0001652582,0.0001226377,0.0002670201,0.0002140804,0.000321776,0.0002040916,0.0002443313,0.0009144176],"category_scores_gemma":[0.00008880096,0.0001593477,0.0001983169,0.0001103004,0.0001956991,0.0001899257,0.0002955176,0.0002334648,0.0003601666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004182832,"about_ca_system_score_gemma":0.0001727401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008193213,"about_ca_topic_score_gemma":0.001592304,"domain_scores_codex":[0.9998726,0.000008747142,0.00001513266,0.00004353995,0.00003828455,0.00002178215],"domain_scores_gemma":[0.9999323,0.000006352789,0.00003147479,0.000009178829,0.000006542445,0.00001414477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003663661,0.000002323608,0.001217108,0.00002054675,0.000003237692,0.00007397075,0.00003136734,0.00003040198,0.9966943,0.0002696839,0.00001009994,0.001610365],"study_design_scores_gemma":[0.00002671687,0.0002728103,0.1295595,0.00004348649,0.00006267957,0.004142033,0.0001794833,0.001018686,0.8463297,0.0007609184,0.01758822,0.00001568929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895645,0.001651292,0.005718105,0.00005649676,0.000009050229,0.00001745223,0.0003170809,0.00006453505,0.002601399],"genre_scores_gemma":[0.9866175,0.0007551615,0.005452699,0.00004116568,0.000005546116,0.00001778775,0.0007376611,0.00002219621,0.006350246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009144176,"threshold_uncertainty_score":0.00305903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174989180986939,"score_gpt":0.2176747871984953,"score_spread":0.205924895388626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}