{"id":"W4288969855","doi":"10.1016/j.jlr.2022.100256","title":"FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses","year":2022,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Dalhousie University; University Health Network; Toronto Metropolitan University; University of Toronto; St. Michael's Hospital","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Ryerson University; Natural Sciences and Engineering Research Council of Canada; St. Michael's Hospital Foundation; St. Michael’s Hospital Foundation; California HIV/AIDS Research Program","keywords":"Acylation; Palmitoylation; Chemistry; Biochemistry; Green fluorescent protein; Spike (software development); Acyltransferase; Enzyme; Cell biology; Biology; Cysteine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417672,0.0002660415,0.0003418605,0.0001212723,0.0000992815,0.0001517584,0.0001931938,0.0002482623,0.0007324695],"category_scores_gemma":[0.0001727848,0.00009923057,0.0002163101,0.0001076751,0.000122654,0.0001029705,0.0001220486,0.0004031928,0.000218352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424732,"about_ca_system_score_gemma":0.0002501121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008720763,"about_ca_topic_score_gemma":0.0009686638,"domain_scores_codex":[0.9998688,0.00002672526,0.00002115576,0.00002075354,0.00003075437,0.00003191937],"domain_scores_gemma":[0.9999354,0.00001388073,0.00001367068,0.000007121093,0.00001069164,0.00001922765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009841401,0.0001222299,0.0002727141,0.00008435037,0.00001646267,0.00005565025,0.00001758035,0.0001364132,0.9954195,0.00007855303,0.0001607955,0.002651541],"study_design_scores_gemma":[0.00007138512,0.00118643,0.002504524,0.000006608397,0.00002017544,0.0002268971,0.00001598474,0.001309569,0.9923887,0.00002251841,0.002242668,0.000004509561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964198,0.00170844,0.0005209764,0.00007980613,0.00004338082,0.00002373505,0.0003341526,0.00006028393,0.0008094803],"genre_scores_gemma":[0.995365,0.000917641,0.001039103,0.00006077195,0.00001111918,0.00003026889,0.000905183,0.000008846497,0.001661978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008720763,"threshold_uncertainty_score":0.002450407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2543261656221071,"score_gpt":0.4860441627112469,"score_spread":0.2317179970891398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}