{"id":"W4289012842","doi":"10.1101/2022.07.29.22278015","title":"Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participants","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University","funders":"Medical Research Council; National Institutes of Health; Vanderbilt University; Office of Research and Development","keywords":"Biology; Disease; Genome-wide association study; Phenome; Genetics; Haematopoiesis; Genome; Mendelian inheritance; Mendelian randomization; Germline; Gene; Stem cell; Single-nucleotide polymorphism; Medicine; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006209704,0.0001707703,0.0002924137,0.000595091,0.0005473731,0.0005607476,0.0003005708,0.0003441705,0.002487115],"category_scores_gemma":[0.001308273,0.0001728159,0.0004133693,0.0008245097,0.0002839575,0.0002457153,0.0007160887,0.0003317717,0.0001578012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001467016,"about_ca_system_score_gemma":0.0001350386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00336232,"about_ca_topic_score_gemma":0.00456226,"domain_scores_codex":[0.9995729,0.0001231925,0.00002091629,0.0001977188,0.0000387154,0.00004651141],"domain_scores_gemma":[0.9995845,0.0001034003,0.00009308216,0.00009870384,0.00005230387,0.00006800353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002978012,0.00001776348,0.9768791,0.00006349583,0.00104165,0.00024927,0.000585682,0.0001460016,0.01005342,0.0003338128,0.000536997,0.009795133],"study_design_scores_gemma":[0.000008106165,0.00006270382,0.9955673,0.00001996431,0.0003589561,0.0006145921,0.000429297,0.0002833614,0.000730868,0.000318737,0.001598359,0.000007833915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970292,0.0005858949,0.000906869,0.00007016942,0.000006270682,0.00000557341,0.001014887,0.00001456073,0.0003664992],"genre_scores_gemma":[0.9987217,0.000130208,0.0003446679,0.00003514087,0.000005163272,0.000008492128,0.0005277813,0.000007920902,0.00021897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00336232,"threshold_uncertainty_score":0.008320272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05261160395550073,"score_gpt":0.3284245770943397,"score_spread":0.275812973138839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}