{"id":"W4289109726","doi":"10.3390/cells11152354","title":"Chronic AMPK Activation Reduces the Expression and Alters Distribution of Synaptic Proteins in Neuronal SH-SY5Y Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"AMPK; AMP-activated protein kinase; Protein kinase A; mTORC1; Synapse; Cell biology; Neurite; Scaffold protein; Biology; Phosphorylation; Chemistry; Signal transduction; Neuroscience; Biochemistry; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031081,0.0001004171,0.0001100854,0.00008972408,0.0003788379,0.00002832914,0.0003930598,0.00002282481,0.00008103215],"category_scores_gemma":[0.0000984759,0.00007848858,0.00002994688,0.0005100318,0.0003770725,0.0001780579,0.0003376277,0.0004236963,0.000005751661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007554313,"about_ca_system_score_gemma":0.00009520454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008908027,"about_ca_topic_score_gemma":3.437613e-7,"domain_scores_codex":[0.9980747,0.0006052437,0.000191466,0.0004209885,0.00041086,0.0002967666],"domain_scores_gemma":[0.9992691,0.0003770104,0.0001108413,0.0001796028,0.00001297836,0.00005044215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006225189,0.00008521802,0.00004322393,0.00001698096,5.018081e-7,0.00001470608,0.0001221544,0.000846156,0.9980178,0.00002993265,0.0002585072,0.0005025444],"study_design_scores_gemma":[0.0003053188,0.0003270079,0.0007552769,0.000009942486,0.000002572246,0.000007431233,0.00004469906,0.001270001,0.9961925,0.00003758356,0.0009792651,0.00006836194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982415,0.00002306023,0.00002006185,0.0007100896,0.0003016436,0.0006174257,0.0000296384,0.00001603682,0.0000405215],"genre_scores_gemma":[0.999327,0.00008875856,0.000002273594,0.0002510192,0.00003546827,0.0001134331,0.000001513008,0.000009691335,0.0001708485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825283,"threshold_uncertainty_score":0.3200671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03499426605252225,"score_gpt":0.30059557022157,"score_spread":0.2656013041690478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}