{"id":"W4289110221","doi":"10.3390/curroncol29080429","title":"Next Wave of Targets in the Treatment of Advanced Renal Cell Carcinoma","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; McMaster University; Western University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Sunitinib; Cancer research; Renal cell carcinoma; Tumor microenvironment; Angiogenesis; Targeted therapy; Cancer; Bioinformatics; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005213157,0.0003364092,0.0007573492,0.0006444585,0.0001827276,0.0007420021,0.0004193909,0.0005282877,0.003850885],"category_scores_gemma":[0.0004573833,0.0001076375,0.0005030459,0.0004194467,0.0002286823,0.0008708871,0.0004723145,0.001526932,0.001313992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003757515,"about_ca_system_score_gemma":0.0007202959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004958662,"about_ca_topic_score_gemma":0.001643846,"domain_scores_codex":[0.9997762,0.00006162155,0.00002206196,0.00002867629,0.00007909972,0.00003229242],"domain_scores_gemma":[0.9998488,0.00005222637,0.00002225413,0.000005230994,0.00005041685,0.0000209826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003043624,0.0001737176,0.0003908613,0.01118443,0.0001559696,0.0003309488,0.0001078111,0.0006524287,0.01049684,0.007191525,0.03790568,0.9311054],"study_design_scores_gemma":[0.00008084644,0.0005477138,0.001129341,0.001736275,0.0001661241,0.001004506,0.00008424541,0.0003773691,0.001906481,0.003098048,0.9898452,0.00002380526],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001199011,0.9924293,0.0009019782,0.001660157,0.0007682971,0.00002196189,0.00007353925,0.00003788633,0.002907825],"genre_scores_gemma":[0.01013815,0.9822162,0.001518081,0.001760778,0.0009177293,0.00004359202,0.0002326359,0.00001028769,0.003162468],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003850885,"threshold_uncertainty_score":0.01288247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2404023940519976,"score_gpt":0.4170973320992331,"score_spread":0.1766949380472354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}