{"id":"W4289130738","doi":"10.1016/j.contraception.2022.07.010","title":"Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy women","year":2022,"lang":"en","type":"article","venue":"Contraception","topic":"Reproductive Health and Contraception","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck Canada; Ipsen; Sigrid Juséliuksen Säätiö; Astellas Pharma; Gedeon Richter; Oregon Health and Science University; Bayer HealthCare; Pfizer; INOVIO Pharmaceuticals; Magee-Womens Research Institute; University of Florida; Suomen Lääketieteen Säätiö; Teva Pharmaceutical Industries; Fuji Pharma","keywords":"Medicine; Drospirenone; Spotting; Body mass index; Breakthrough bleeding; Odds ratio; Menstrual cycle; Confidence interval; Pill; Gynecology; Internal medicine; Obstetrics; Population; Family planning; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01696144,0.002383859,0.01017261,0.00173274,0.0004731579,0.002585847,0.0008637202,0.002038212,0.00458582],"category_scores_gemma":[0.02861545,0.0009509823,0.02265075,0.001855385,0.0005804863,0.001267316,0.001034902,0.001735033,0.0004002543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001115803,"about_ca_system_score_gemma":0.001505093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494412,"about_ca_topic_score_gemma":0.003558586,"domain_scores_codex":[0.9858747,0.009241121,0.002340772,0.001179433,0.0009946473,0.0003693306],"domain_scores_gemma":[0.9848941,0.007577599,0.004850796,0.0009854571,0.001257895,0.0004340724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.3308268,0.0003974615,0.00600846,0.0314639,0.6089844,0.0001549541,0.00007368078,0.0009835588,0.001143879,0.0001209635,0.001448644,0.01839321],"study_design_scores_gemma":[0.2007079,0.02116045,0.0279027,0.003512092,0.7407563,0.0002200763,0.0001126596,0.001056231,0.000746157,0.0005094438,0.003216968,0.0000991106],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3700058,0.5896155,0.007400062,0.001684682,0.002381235,0.009302698,0.01271096,0.0004990173,0.006400147],"genre_scores_gemma":[0.9336466,0.04818422,0.004547232,0.001691122,0.0006663923,0.005778907,0.003712089,0.00007287872,0.001700618],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01696144,"threshold_uncertainty_score":0.08970177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.077232666629429,"score_gpt":0.4266180002228844,"score_spread":0.3493853335934554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}