{"id":"W4289130738","doi":"10.1016/j.contraception.2022.07.010","title":"Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy women","year":2022,"lang":"en","type":"article","venue":"Contraception","topic":"Reproductive Health and Contraception","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck Canada; Ipsen; Sigrid Juséliuksen Säätiö; Astellas Pharma; Gedeon Richter; Oregon Health and Science University; Bayer HealthCare; Pfizer; INOVIO Pharmaceuticals; Magee-Womens Research Institute; University of Florida; Suomen Lääketieteen Säätiö; Teva Pharmaceutical Industries; Fuji Pharma","keywords":"Medicine; Drospirenone; Spotting; Body mass index; Breakthrough bleeding; Odds ratio; Menstrual cycle; Confidence interval; Pill; Gynecology; Internal medicine; Obstetrics; Population; Family planning; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00969303,0.0002879406,0.002000567,0.000835033,0.0002203129,0.00001701438,0.0001539342,0.00008635715,0.0002319108],"category_scores_gemma":[0.003712772,0.0002334987,0.0003787186,0.001425697,0.0001059355,0.0001325236,0.00005295668,0.0006251559,0.000001371342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001016363,"about_ca_system_score_gemma":0.00035933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004671345,"about_ca_topic_score_gemma":0.00008049214,"domain_scores_codex":[0.9944777,0.001680327,0.00175095,0.000607101,0.0009005859,0.0005833328],"domain_scores_gemma":[0.9947739,0.002526514,0.00165638,0.0005061141,0.0003726796,0.0001643975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07782475,0.005388201,0.03925798,0.0005183072,0.002799938,0.00002363027,0.01577217,0.006500373,0.7179481,0.00066001,0.00001678422,0.1332897],"study_design_scores_gemma":[0.2256736,0.1051387,0.4259586,0.000842978,0.009341852,0.00002444849,0.01782767,0.2091414,0.005092564,0.0002109402,0.0000433965,0.0007038114],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910282,0.0004789061,0.0030542,0.001031171,0.0005306044,0.003700177,0.00008568299,0.00003862207,0.00005239359],"genre_scores_gemma":[0.9976562,0.00004577238,0.00009817832,0.000663103,0.0001914915,0.001113967,0.000124915,0.00003084899,0.00007551051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7128556,"threshold_uncertainty_score":0.9521799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.077232666629429,"score_gpt":0.4266180002228844,"score_spread":0.3493853335934554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}