{"id":"W4289132938","doi":"10.1111/tra.12863","title":"Evolution of factors shaping the endoplasmic reticulum","year":2022,"lang":"en","type":"article","venue":"Traffic","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Endomembrane system; Endoplasmic reticulum; Biology; Organelle; Cell biology; Lineage (genetic); Function (biology); Most recent common ancestor; Organelle biogenesis; Biogenesis; Computational biology; Evolutionary biology; Genetics; Golgi apparatus; Genome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104304,0.00005875218,0.00005754332,0.0000201045,0.0001254063,0.000002951898,0.0001186664,0.00002836707,0.0001021397],"category_scores_gemma":[0.000005811724,0.00004716936,0.00007820204,0.0000739626,0.00004352993,9.6139e-7,0.00002706573,0.00007351255,0.000001296552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001328935,"about_ca_system_score_gemma":0.0000341196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000128303,"about_ca_topic_score_gemma":0.00002403125,"domain_scores_codex":[0.9995186,0.00003922973,0.0001092353,0.0001227644,0.0001121359,0.00009806224],"domain_scores_gemma":[0.9997653,0.000005104395,0.00004507236,0.0001531835,0.00001508746,0.00001626034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006159995,0.00004642318,0.003666082,0.00001089142,0.00002265677,0.000001030303,0.0003481164,0.01150619,0.9836287,0.0003942708,0.0001006807,0.0002133959],"study_design_scores_gemma":[0.001906312,0.001340499,0.06755187,0.00001873748,0.0001717351,0.00006191362,0.006138027,0.01017212,0.6977545,0.0001344335,0.2140492,0.0007005714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978223,0.0005760475,0.0009490618,0.0000463526,0.00013809,0.00009762993,0.00001278869,0.000009226927,0.0003484354],"genre_scores_gemma":[0.999182,0.00001927095,0.00001191564,0.00001555148,0.00003854761,0.000009380939,0.0005611894,0.000008171497,0.0001539369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2858741,"threshold_uncertainty_score":0.1923511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272574986453471,"score_gpt":0.2072577825709418,"score_spread":0.1945320327064071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}