{"id":"W4289209710","doi":"10.1039/d2bm00293k","title":"The maternal-fetal transfer of passive immunity as a mechanism of transplacental nanoparticle drug delivery for prenatal therapies","year":2022,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex (Canada); University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Research Manitoba","keywords":"Transplacental; Fetus; Drug delivery; Nanoparticle; Passive immunity; Neonatal Fc receptor; Chemistry; Placenta; Fetal circulation; Biophysics; Chitosan; Antibody; Immunity; Immunology; Medicine; Nanotechnology; Immunoglobulin G; Pregnancy; Immune system; Materials science; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005396566,0.000350194,0.0001342472,0.0003265889,0.0002229029,0.0004120886,0.0003121364,0.0007335792,0.002486226],"category_scores_gemma":[0.0003596031,0.0001688851,0.0002594285,0.0001192606,0.0004706568,0.0004946827,0.0004810913,0.0009136769,0.0003700526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005120746,"about_ca_system_score_gemma":0.0003802485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005909531,"about_ca_topic_score_gemma":0.0006743354,"domain_scores_codex":[0.9997389,0.00007455902,0.00001379769,0.00005088238,0.00007380383,0.00004805993],"domain_scores_gemma":[0.9998578,0.00004769464,0.00003707402,0.00001696127,0.00002460869,0.000015867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007880649,0.0000520535,0.0003278097,0.0001815034,0.00001013084,0.00009025984,0.00004791447,0.00008764459,0.9832614,0.003947254,0.0001838542,0.01173145],"study_design_scores_gemma":[0.00001560418,0.0002322806,0.00200202,0.00002520338,0.00002144293,0.0003952972,0.00004374767,0.001023159,0.9871147,0.0004805857,0.008637852,0.000008064576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.831764,0.03644804,0.1035226,0.002818893,0.0007671979,0.0002429992,0.0003271717,0.0003661634,0.02374302],"genre_scores_gemma":[0.9751985,0.004486227,0.01278074,0.0003190044,0.00004111394,0.0001172302,0.00006298155,0.00002058054,0.006973593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002486226,"threshold_uncertainty_score":0.008317292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042499580896308,"score_gpt":0.2308973000931012,"score_spread":0.2204723042841381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}