{"id":"W4289222504","doi":"10.15698/cst2022.08.270","title":"Cardiac PI3K p110α attenuation delays aging and extends lifespan","year":2022,"lang":"en","type":"letter","venue":"Cell Stress","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Labex Immuno-Oncology; Fondation pour la Recherche Médicale; Horizon 2020 Framework Programme; Medizinische Universität Graz; Tiroler Wissenschaftsförderung; Institut Universitaire de France; Österreichische Kardiologische Gesellschaft; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National Du Cancer; High-end Foreign Experts Recruitment Plan of China; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Institut National de la Santé et de la Recherche Médicale; Austrian Science Fund; HORIZON EUROPE Framework Programme; Fondation Leducq; Agence Nationale de la Recherche; Université de Paris; Association pour la Recherche sur le Cancer; Seerave Foundation; Institut Gustave-Roussy; European Commission; Karl-Franzens-Universität Graz; Equipex","keywords":"Attenuation; Medicine; Physics; Optics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001591521,0.0003921608,0.000325068,0.00008613387,0.0002391559,0.00009276775,0.0003634348,0.0005686815,0.0001498494],"category_scores_gemma":[0.00001779093,0.0004454733,0.0001617881,0.00006083685,0.00009889057,0.000003463241,0.0004272876,0.0007773019,0.00001287773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003434251,"about_ca_system_score_gemma":0.00007814997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008842285,"about_ca_topic_score_gemma":0.0000112069,"domain_scores_codex":[0.9979943,0.0001751869,0.0002665521,0.0007903776,0.0003176619,0.0004559263],"domain_scores_gemma":[0.9989479,0.00002287149,0.0001866058,0.0006803402,0.00007408431,0.00008821638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000163945,0.0000494118,0.005524294,0.000425272,0.000141232,0.00006753713,0.0006053639,0.000399154,0.03995278,0.000002300049,0.9511999,0.001616324],"study_design_scores_gemma":[0.0003219231,0.0001990368,0.0009819204,0.00002060531,0.000181632,0.00001190589,0.0001405908,0.0001042251,0.04155616,0.00002918531,0.9557545,0.0006983289],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8743119,0.0262141,0.003125751,0.08071478,0.005221235,0.00127202,0.001565145,0.0001352481,0.00743978],"genre_scores_gemma":[0.7993444,0.004345396,0.0007801303,0.1439211,0.01245615,0.0001746885,0.01352544,0.00038032,0.02507236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07496758,"threshold_uncertainty_score":0.9997997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008989021060218271,"score_gpt":0.2152565007563466,"score_spread":0.2062674796961283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}