{"id":"W4289261303","doi":"10.1158/0008-5472.can-21-3956","title":"Germline Missense Variants in <i>CDC20</i> Result in Aberrant Mitotic Progression and Familial Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; Institute for Research in Immunology and Cancer; McGill University and Génome Québec Innovation Centre; Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Biology; CDC20; Spindle checkpoint; Cancer research; Missense mutation; Mitosis; Genetics; Cell cycle; Cancer; Mutation; Spindle apparatus; Cell division; Gene; Cell; Anaphase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009559773,0.001111712,0.0008423462,0.0007243258,0.000890189,0.0009403322,0.001119337,0.008068297,0.003573742],"category_scores_gemma":[0.001448571,0.0003935878,0.0005691365,0.0003914176,0.001505173,0.0005350872,0.0005243411,0.006610187,0.002282934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001870161,"about_ca_system_score_gemma":0.000690426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0055621,"about_ca_topic_score_gemma":0.01255606,"domain_scores_codex":[0.9992839,0.00009498945,0.00006735003,0.0002329481,0.0002469713,0.00007404322],"domain_scores_gemma":[0.9990338,0.0005418099,0.00006198753,0.00002602325,0.0002003009,0.0001361312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0003820972,0.00006638309,0.001246523,0.0002848521,0.00008968639,0.009162615,0.0001078106,0.0001631222,0.007717315,0.002693169,0.9346622,0.04342424],"study_design_scores_gemma":[0.0003204783,0.0002872343,0.01582445,0.0006958423,0.0002759843,0.01885453,0.0002270713,0.0007329072,0.009910643,0.006685991,0.9460654,0.0001194081],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01628745,0.1035512,0.002127005,0.7134382,0.1250018,0.0001688074,0.001254175,0.0009615619,0.0372098],"genre_scores_gemma":[0.1129078,0.1073289,0.001942794,0.4256134,0.2374986,0.0002358747,0.0006715576,0.0003026404,0.1134985],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008068297,"threshold_uncertainty_score":0.013569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03220888370232307,"score_gpt":0.3738851677885472,"score_spread":0.3416762840862242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}