{"id":"W4289261556","doi":"10.1016/j.apsb.2022.07.016","title":"Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators","year":2022,"lang":"en","type":"article","venue":"Acta Pharmaceutica Sinica B","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Sponsorship Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; European Commission; CALIPSOplus; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Pfizer","keywords":"NAD+ kinase; Nicotinamide phosphoribosyltransferase; Chemistry; Activator (genetics); Nicotinamide adenine dinucleotide; Nicotinamide; Biochemistry; Cofactor; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087621,0.0002214285,0.0005469966,0.0001299346,0.0002229969,0.00001137182,0.0005183886,0.000103925,0.000131328],"category_scores_gemma":[0.0009773662,0.0001375805,0.0001954651,0.0009854622,0.0005741596,0.0001787339,0.0002246208,0.001131988,4.268925e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001563838,"about_ca_system_score_gemma":0.0004544234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971776,"about_ca_topic_score_gemma":0.000008780965,"domain_scores_codex":[0.9973145,0.000320283,0.0008958825,0.0003173943,0.0008684702,0.0002834528],"domain_scores_gemma":[0.9970916,0.001287665,0.0006518299,0.0007512692,0.0001202049,0.00009746046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001021241,0.0005848449,0.004096293,0.0002785068,0.0002326482,0.000006118494,0.005519059,0.0003146556,0.9848981,0.00006295047,0.001894424,0.001091146],"study_design_scores_gemma":[0.004660164,0.0003486449,0.005712986,0.0003004254,0.0004594549,0.0000420156,0.01431642,0.009654094,0.9459729,0.0001150593,0.01822045,0.0001973812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869383,0.0001403568,0.00001989173,0.01048993,0.0002322404,0.0006355884,0.00004051361,0.00001586172,0.001487289],"genre_scores_gemma":[0.9984083,0.0002370148,0.000152862,0.0007097302,0.0001777789,0.00008668999,0.00005922026,0.00003048922,0.0001379464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03892521,"threshold_uncertainty_score":0.5610368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926388608964843,"score_gpt":0.3745634817343813,"score_spread":0.3352995956447328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}