{"id":"W4289261556","doi":"10.1016/j.apsb.2022.07.016","title":"Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators","year":2022,"lang":"en","type":"article","venue":"Acta Pharmaceutica Sinica B","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Sponsorship Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; European Commission; CALIPSOplus; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Pfizer","keywords":"NAD+ kinase; Nicotinamide phosphoribosyltransferase; Chemistry; Activator (genetics); Nicotinamide adenine dinucleotide; Nicotinamide; Biochemistry; Cofactor; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004437345,0.0004985518,0.0002930075,0.0002996469,0.0002633021,0.0002866425,0.0003429072,0.000417177,0.00312618],"category_scores_gemma":[0.0002969016,0.0001873455,0.0004592538,0.0002408874,0.0004612188,0.0007240691,0.0004162796,0.001255115,0.0006998762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000435496,"about_ca_system_score_gemma":0.0003595104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003583707,"about_ca_topic_score_gemma":0.0008495905,"domain_scores_codex":[0.9998542,0.00004199845,0.00000641249,0.00003700085,0.00003486834,0.00002538512],"domain_scores_gemma":[0.9999061,0.00002928503,0.00001993345,0.000008451962,0.00002318902,0.00001301066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004582953,0.0004188142,0.0004436912,0.001397097,0.00006225892,0.0004496431,0.0002624044,0.002615029,0.9308422,0.01431408,0.000734965,0.04800149],"study_design_scores_gemma":[0.0001373895,0.005105378,0.00116449,0.0001279549,0.0000538059,0.0007953874,0.000131965,0.002509914,0.9341656,0.004284731,0.05146803,0.00005530515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6310949,0.1524063,0.1283614,0.003771864,0.0009229477,0.001228027,0.0009689839,0.0003723745,0.08087333],"genre_scores_gemma":[0.8857283,0.07359983,0.02737888,0.0009315744,0.0001687411,0.0002358405,0.0003209194,0.00004870359,0.01158725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00312618,"threshold_uncertainty_score":0.01045811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926388608964843,"score_gpt":0.3745634817343813,"score_spread":0.3352995956447328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}