{"id":"W4289262185","doi":"10.1371/journal.pbio.3001740","title":"Phage endolysins are adapted to specific hosts and are evolutionarily dynamic","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Lysin; Biology; Bacteriophage; Lytic cycle; Genetics; Genome; Lysogenic cycle; Gene; Escherichia coli; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000296873,0.0004147312,0.0004392888,0.0003968265,0.0003613418,0.000851906,0.000261279,0.0005671362,0.0006138207],"category_scores_gemma":[0.0006077747,0.0002278175,0.0002819685,0.0004701257,0.0005655721,0.0006855162,0.001107704,0.0007514532,0.000401381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003668434,"about_ca_system_score_gemma":0.000233871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002494636,"about_ca_topic_score_gemma":0.0003175121,"domain_scores_codex":[0.999679,0.00005584735,0.00002231864,0.0001065887,0.00007058952,0.00006577754],"domain_scores_gemma":[0.9995831,0.00006882394,0.0001665817,0.00007578103,0.00004285913,0.00006279964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001518482,0.00003499171,0.01178962,0.0001288495,0.00004303968,0.0003716423,0.0001709232,0.0006688971,0.9658833,0.001660168,0.0001331159,0.01896366],"study_design_scores_gemma":[0.00003935132,0.0009396203,0.2487215,0.0001047611,0.0001676184,0.01179246,0.0009204342,0.008458096,0.6562681,0.007030328,0.06539699,0.0001608301],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983538,0.002810311,0.01005966,0.0001475815,0.00003227384,0.00001951903,0.0002070725,0.0001591374,0.003026527],"genre_scores_gemma":[0.9890974,0.001566371,0.006097889,0.0001226007,0.0000167137,0.0000258016,0.0005165343,0.00006439125,0.002492395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000851906,"threshold_uncertainty_score":0.002661586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323103400898916,"score_gpt":0.2251043942482933,"score_spread":0.2118733602393041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}