{"id":"W4289262185","doi":"10.1371/journal.pbio.3001740","title":"Phage endolysins are adapted to specific hosts and are evolutionarily dynamic","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Lysin; Biology; Bacteriophage; Lytic cycle; Genetics; Genome; Lysogenic cycle; Gene; Escherichia coli; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004194155,0.00009476028,0.0001258584,0.00004394204,0.0002679869,0.00001326967,0.0001417242,0.00003371281,0.007282314],"category_scores_gemma":[0.00001251171,0.00009402363,0.00003183218,0.0001492477,0.00008098736,0.00005567744,0.0004192733,0.0001500461,0.000422001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002131433,"about_ca_system_score_gemma":0.00000360634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001348218,"about_ca_topic_score_gemma":0.0003254642,"domain_scores_codex":[0.999245,0.00006999363,0.000114356,0.0003128745,0.00005141027,0.0002063191],"domain_scores_gemma":[0.9996712,0.00002894694,0.00006675185,0.0001574292,0.000004878493,0.00007085673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003022156,0.0001266329,0.0076528,0.000001574027,0.00001424797,0.00001358256,0.0001646123,0.0000511807,0.9869978,0.00004430917,0.003255793,0.001647219],"study_design_scores_gemma":[0.000279454,0.0002154245,0.671118,0.000006849792,0.00001441386,0.00009568499,0.0004926986,0.0002792698,0.001641888,0.0001041853,0.325526,0.000226132],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966437,0.0001509011,0.0001035745,0.001360856,0.0002559258,0.0001774797,0.0002749235,0.0000380639,0.0009946298],"genre_scores_gemma":[0.9976988,0.00003089858,0.0003371334,0.0005877764,0.00002718344,0.00004529477,0.00004392119,0.000009799394,0.001219211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9853559,"threshold_uncertainty_score":0.9936252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323103400898916,"score_gpt":0.2251043942482933,"score_spread":0.2118733602393041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}