{"id":"W4289316217","doi":"10.1002/ana.26467","title":"Effect Modification between Genes and Environment and Parkinson's Disease Risk","year":2022,"lang":"en","type":"review","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institutes of Health; Barts Charity; Michael J. Fox Foundation for Parkinson's Research","keywords":"Penetrance; Disease; Etiology; Parkinson's disease; Bioinformatics; Medicine; Neuroscience; Biology; Genetics; Gene; Pathology; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006677318,0.0007228805,0.001205244,0.001073765,0.0001373994,0.0006357775,0.0006207112,0.0008319368,0.00334163],"category_scores_gemma":[0.001197592,0.0001677058,0.0007434485,0.0009492605,0.0003243963,0.0003846606,0.0003399236,0.0009818367,0.001102558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004071585,"about_ca_system_score_gemma":0.0005644076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003117,"about_ca_topic_score_gemma":0.001555903,"domain_scores_codex":[0.9997913,0.00007137611,0.00002923549,0.00004601511,0.00005126395,0.00001090749],"domain_scores_gemma":[0.9994599,0.0004122711,0.0000486562,0.00001199897,0.00005125736,0.00001599135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001374995,0.00004979456,0.0008761328,0.0129652,0.0005482463,0.0002663536,0.00004561112,0.0003555099,0.001067383,0.003521306,0.01345443,0.9667126],"study_design_scores_gemma":[0.00009133601,0.0003384546,0.01166544,0.01409679,0.002131299,0.004750714,0.00008858375,0.0003718548,0.001692234,0.01011012,0.9545971,0.0000661498],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002206037,0.9980099,0.0002492569,0.0003944375,0.0001668234,0.000003864267,0.00003763923,0.000009862484,0.0009077229],"genre_scores_gemma":[0.00233282,0.9959226,0.0004845654,0.0003217223,0.000242012,0.00001286054,0.0000540177,0.000003144129,0.0006264148],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00334163,"threshold_uncertainty_score":0.01117879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09356351230938818,"score_gpt":0.3566563379418768,"score_spread":0.2630928256324886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}