{"id":"W4289344227","doi":"10.21203/rs.3.rs-1886575/v1","title":"Backbone and side-chain resonance assignments of the NISTmAb-scFv and antigen-binding study","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Antigen; Immunoglobulin light chain; Monoclonal antibody; Antibody; Peptide; Single-chain variable fragment; Chemistry; Computational biology; Molecular biology; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740235,0.0001719754,0.0001248192,0.0002393779,0.000243761,0.00009431788,0.0003018179,0.0002942238,0.001729544],"category_scores_gemma":[0.0002252002,0.00007324751,0.0001639192,0.0002325921,0.0001951115,0.0001500364,0.0001302886,0.0003404732,0.0002223547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033098,"about_ca_system_score_gemma":0.0001940442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001359923,"about_ca_topic_score_gemma":0.001024005,"domain_scores_codex":[0.9998997,0.00001439596,0.000002961692,0.00002276857,0.00003270174,0.00002747514],"domain_scores_gemma":[0.9998835,0.00002159201,0.00002621061,0.0000110917,0.00003444456,0.00002312549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009830658,0.00001809191,0.0003433701,0.00002152428,0.000005118538,0.00005381477,0.00002526236,0.0002218015,0.9972214,0.000145206,0.00009309105,0.001753106],"study_design_scores_gemma":[0.00001169769,0.0002297772,0.006878665,0.000006569031,0.00002017989,0.0002050617,0.0000416454,0.003668761,0.9866389,0.00009120618,0.002199742,0.000007714712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911397,0.0004739143,0.004907315,0.00005527254,0.00002545224,0.00001289677,0.0002100194,0.00004178091,0.0031336],"genre_scores_gemma":[0.9936878,0.0001943829,0.00395307,0.00003839031,0.000008148195,0.0000107922,0.0004797517,0.00001075297,0.001616898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729544,"threshold_uncertainty_score":0.005785942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09845052182085279,"score_gpt":0.4327807813748881,"score_spread":0.3343302595540353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}