{"id":"W4289348296","doi":"10.3390/molecules27154854","title":"Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Receptor; Angiotensin II receptor type 1; Angiotensin II; Chemistry; Agonist; Pharmacology; Angiotensin receptor; Inverse agonist; Renin–angiotensin system; G protein-coupled receptor; Internal medicine; Endocrinology; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001286601,0.0002794109,0.0004695739,0.0001533038,0.0005097608,0.00003018382,0.0003368762,0.0001674078,0.000009970798],"category_scores_gemma":[0.0003493836,0.0001976852,0.0003544927,0.0003658035,0.0002250743,0.00000549907,0.0001941429,0.0001740444,2.708076e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008951552,"about_ca_system_score_gemma":0.0001415987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004661143,"about_ca_topic_score_gemma":0.00007199292,"domain_scores_codex":[0.9977024,0.0005682408,0.0005350955,0.0005009755,0.00035437,0.0003389122],"domain_scores_gemma":[0.9984434,0.0004544898,0.0003988227,0.000508599,0.0001202184,0.00007451046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001140493,0.0001218839,0.0000737536,0.0000486064,0.0001371557,0.000003296902,0.00171546,0.002103156,0.9900727,0.001391299,0.002014879,0.001177309],"study_design_scores_gemma":[0.00581466,0.0007121604,0.0002211063,0.00009218483,0.0001290029,0.00005201008,0.002074268,0.003220991,0.952511,0.0001049994,0.03468631,0.0003813316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985047,0.004138407,0.006082126,0.002678046,0.0004679208,0.001406406,0.0001454273,0.00001996705,0.00001465064],"genre_scores_gemma":[0.9947487,0.0002340636,0.003723756,0.0007181592,0.0001483764,0.0001443444,0.0001762299,0.000052293,0.00005405316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03756174,"threshold_uncertainty_score":0.8061368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186982150772689,"score_gpt":0.2512304376016289,"score_spread":0.23253222252436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}