{"id":"W4289348296","doi":"10.3390/molecules27154854","title":"Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Receptor; Angiotensin II receptor type 1; Angiotensin II; Chemistry; Agonist; Pharmacology; Angiotensin receptor; Inverse agonist; Renin–angiotensin system; G protein-coupled receptor; Internal medicine; Endocrinology; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770783,0.0003078032,0.0003851007,0.0001632927,0.00009695467,0.0003551895,0.0002090624,0.0002048576,0.001656603],"category_scores_gemma":[0.0001537882,0.00009955908,0.0002438549,0.0001057859,0.000134697,0.0001677812,0.00009936892,0.0004187949,0.0004169613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815756,"about_ca_system_score_gemma":0.0002039101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003959223,"about_ca_topic_score_gemma":0.0007250651,"domain_scores_codex":[0.9998606,0.00003235014,0.000009302918,0.00002089626,0.00005398098,0.0000228004],"domain_scores_gemma":[0.9999464,0.00001195533,0.0000168719,0.000003081699,0.000008658373,0.00001297152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005543714,0.0002439724,0.0007375844,0.0002495842,0.00003356606,0.0001449393,0.00001628505,0.001953241,0.9754211,0.0003266037,0.000193637,0.02012494],"study_design_scores_gemma":[0.0001919294,0.003576904,0.005495078,0.00002952096,0.0001781816,0.0008821945,0.00005097729,0.01093857,0.9654419,0.0003017108,0.01287287,0.00004011061],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576858,0.02297935,0.01155554,0.0004681248,0.000173845,0.00009645242,0.000585763,0.000204901,0.006250179],"genre_scores_gemma":[0.9869955,0.004447708,0.006465834,0.0001244554,0.00003926962,0.00002228622,0.0003533005,0.00001833082,0.001533273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656603,"threshold_uncertainty_score":0.005541861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186982150772689,"score_gpt":0.2512304376016289,"score_spread":0.23253222252436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}