{"id":"W4289515481","doi":"10.1158/1538-7445.sabcs21-pd4-04","title":"Abstract PD4-04: Updated results of tucatinib vs placebo added to trastuzumab and capecitabine for patients with previously treated HER2-positive metastatic breast cancer with brain metastases (HER2CLIMB)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Capecitabine; Medicine; Metastatic breast cancer; Regimen; Internal medicine; Oncology; Trastuzumab; Placebo; Breast cancer; Population; Cancer; Colorectal cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002932256,0.001412285,0.003104194,0.0007183655,0.000350598,0.001454091,0.001291589,0.001278999,0.004895607],"category_scores_gemma":[0.0029719,0.0005707496,0.00434136,0.0006307731,0.0006125336,0.001050354,0.0005052112,0.003224789,0.0008748632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001431691,"about_ca_system_score_gemma":0.00135275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001527078,"about_ca_topic_score_gemma":0.002619062,"domain_scores_codex":[0.9984105,0.0009764357,0.0001282243,0.0001739985,0.0001493333,0.0001614751],"domain_scores_gemma":[0.9983348,0.0004741427,0.0004417488,0.0001723603,0.0001927731,0.0003841828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9398864,0.006264379,0.002278264,0.0005671632,0.00430833,0.00007668319,0.0000617163,0.0006982114,0.003852853,0.00007413961,0.001871673,0.0400602],"study_design_scores_gemma":[0.7065203,0.255311,0.02191353,0.000104518,0.00845869,0.0001766328,0.00004949598,0.0009912011,0.002345453,0.000236272,0.003842375,0.00005064163],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781181,0.009790653,0.0006418745,0.000722061,0.0004523293,0.001688108,0.004805075,0.0001716939,0.003610088],"genre_scores_gemma":[0.9860699,0.002484497,0.0009352019,0.0009559973,0.0003908949,0.001243724,0.005305037,0.00003837641,0.002576447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004895607,"threshold_uncertainty_score":0.01637739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03533597802169067,"score_gpt":0.3621909480056609,"score_spread":0.3268549699839702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}