{"id":"W4289515481","doi":"10.1158/1538-7445.sabcs21-pd4-04","title":"Abstract PD4-04: Updated results of tucatinib vs placebo added to trastuzumab and capecitabine for patients with previously treated HER2-positive metastatic breast cancer with brain metastases (HER2CLIMB)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Capecitabine; Medicine; Metastatic breast cancer; Regimen; Internal medicine; Oncology; Trastuzumab; Placebo; Breast cancer; Population; Cancer; Colorectal cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001195988,0.0003908181,0.0008634132,0.0004109205,0.0003786435,0.00004487031,0.0001988603,0.00003986518,0.000973875],"category_scores_gemma":[0.0001364543,0.0002689048,0.00009389897,0.001176877,0.0002674926,0.0001164133,0.0001230893,0.000431359,0.000003081012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007614756,"about_ca_system_score_gemma":0.001018767,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007099833,"about_ca_topic_score_gemma":0.001956426,"domain_scores_codex":[0.9961117,0.0004046243,0.0005406455,0.0008719263,0.001226866,0.00084424],"domain_scores_gemma":[0.9968984,0.0007953919,0.0002359037,0.0005149094,0.001060475,0.0004949847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6324642,0.01857919,0.05855162,0.003065039,0.01466012,0.0007927814,0.01330047,0.002589917,0.007573402,0.0001178148,0.1351117,0.1131937],"study_design_scores_gemma":[0.1563465,0.06844159,0.7196941,0.002565464,0.003543254,0.0002208013,0.008071748,0.0002277027,0.02037897,0.00003868506,0.0189362,0.001534985],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96695,0.0005580928,0.00002402843,0.004980555,0.00003526377,0.006646676,0.02063658,0.00003122105,0.0001376013],"genre_scores_gemma":[0.9898975,0.0000783776,0.001236328,0.0003087606,0.00005093268,0.005252273,0.002123968,0.0001023614,0.0009494859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6611425,"threshold_uncertainty_score":0.9999763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03533597802169067,"score_gpt":0.3621909480056609,"score_spread":0.3268549699839702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}